CLL RELAPSE.. LATEST TREATMENTS AVAILABLE

[theoptimistduo]

Hi all..

Patient was diagnosed with CLL in 2017 as he was at stage 0

2018- reached Rai stage 3.. FCR was given starting with immunotherapy

2019- relapse of CLL- started having Ibrutinib

2020 Nov- got covid ( episode 1)

2021- April - COVID ( episode2)

June- relapse of CLL as Ibrutinib stopped working .. there was a suspicion of DLBCL so RCHOP one cycle was given but patient wasn’t able to tolerate so it was stopped. After 3 months of hospitalisation and multiple blood and platelets transfusion, he was discharged and put on Rituximab + Venitoclax ( could go upto 200 mg only)

2022- March - COVID (episode 3)

as of today- CLL has relapsed again .. the doctors are discussing various new combinations to treat it.. patient developed H1N1 recently and is hospitalised for treatment of lung infection

## is there anyone in the group with multiple relapses or a case similar to this ?

## what all treatment options did you go for

## please share experiences and pour in your advices

thank you in advance!!

[lankisterguy Volunteer]

Hi auuspa,

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We would like to help you, but are not certain what country, health system and your relationship to the patient is involved.

Knowing the patient's geno immunotype profile would also help. These come from FISH testing and IGHV tests, as well as several Next Generation Sequencing.

Can you please complete your profile and provide those details.

See: #3 on this Pinned Post: healthunlocked.com/cllsuppo....

healthunlocked.com/user/ayuspa

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I see you also posted to the inactive CLL America group,

healthunlocked.com/cll-amer...

so you may be in the USA or at least the Americas. Unfortunately that group has low participation and no moderators. So we USA patients are here in the international group.

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If you view my profile and history healthunlocked.com/user/lan... I believe I meet your requested experiences.

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However the use of FCR in 2017 would be unusual in the USA if a CLL expert doctor was involved.

Has the patient consulted one of the top CLL experts?

See cllsociety.org/newly-diagno...

and if not then you may want to arrange a consult here: cllsociety.org/programs-and...

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Len

[skipro]

Current recommendations are

Venetoclax plus Obituzimab rather than Rituximab

Ven + Ibr

Newer treatments for refractory or relapsed patients include:

Luxeptinib

Entospletinib + Obituzimab

But with your situation, you may need a clinical trial treatment like

Bruin study using Pirtobrutinib

PROTAC

iDuo NK cell, FT596. is in Phase 1 clinical trial (NCT04245722) is underway, This is an upgrade from CAR-T cell

PTK inhibitors ( I am being considered for this study with my relapsed CLL. The Center with the most experience is the Huntsman Cancer Center and the U of U in Salt Lake City, Utah.

Good luck and may God bless

snowshoe

AKA Dr Green