Sotrovimab or Paxlovid with Ibrutinib

[RobertCLL]

Should one stop taking Ibrutinib if receiving Sotrovimab or Paxlovid for COVID?

Just a precautionary question.

[bennevisplace]

Check with physician.

Listed drug interactions Sotrovimab webmd.com//drugs/2/drug-181... and Paxlovid webmd.com/drugs/2/drug-1832...

[lankisterguy Volunteer]

Hi RobertCLL,

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We have had several recent discussions about the interaction of Paxlovid. The bottom line is that Paxlovid is taken for 5 days, and during those days only (no pause before or after) your doctor should modify your dose to reduce or pause taking Ibrutinib.

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See healthunlocked.com/cllsuppo...

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Len

[Sumoldbloke in reply to lankisterguy]

Does this also apply to Venetoclax? It would appear so from the drug interactions reference cited?

[lankisterguy Volunteer in reply to Sumoldbloke]

Yes,

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It applies to all the CLL drugs that have a "grapefruit" warning ( to avoid CYP3A inhibitors). Paxlovid will cause those drugs to act much stronger and stay in your blood much longer, possibly making side effects worse.

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Len

[Sumoldbloke in reply to lankisterguy]

Many thanks for such a quick reply. I am hoping not to require any of these measures as I am living like a hermit whilst going through first line O& V treatment but better to know just in case so it looks as if it would be sotrovimab for me or a pause in Venetoclax if doctor advises. Think I will maintain my undercover status till treatment is over.

[lankisterguy Volunteer in reply to Sumoldbloke]

Hi Sumoldbloke,

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There seems to be some indications that the latest sub variant can overcome sotrovimab, so Dr. Furman is recommending Paxlovid for COVID positive / exposed patients and Evusheld as preventive / prophylactic. -

Len

[lankisterguy Volunteer in reply to Sumoldbloke]

healthunlocked.com/cllsuppo....

[RobertCLL]

Many thanks for the replies. Just spoken to my GP, and having my recorded amended to state that Paxlovid is contraindicated for me. Therefore, Sotrovimab should be administered.

As I said just a precautionary activity, just in case.

[lankisterguy Volunteer]

healthunlocked.com/cllsuppo....