I was diagnosed with CLL about 3 months ago. Doctor put me on leukeran for about 4 weeks then switched to ibrutinib. White cell count dropped from a high of 88,000 to 20,000 but as that was taking place my heart went in to afib and I was short of breath and couldn't fall asleep. We had to discontinue the chemo and take water pills as I had suddenly gained nearly 10 lbs. Now I feel better and have lost most of the extra fluid but don't know if I should consider going back on ib or what. Maybe a lower dosage would be ok.