Nitric Oxide

[Vindicatrix]

I am always lookng for ways to assist me, as I travel through the quagmire of information and misinformation, which seems to exsist for most oif us CLL'rs. As a result, I have been researching, Nitric Oxide (NO).

I have absolutely no experience at all, in Science and Chemistry, so this will have to be in very simple Laymen's Term's, I'm afraid.

I first looked into this subject, whilst engaging in Slow, Long Breathing, through the nose, which I was told was, helpful to our' Immune System's. It seems that there has been much research on this, and the effects Nitric Oxide on the Immune System.

A Doctor Lou Ignarro, a Physiologist, obtained the 'Nobel Peasce Prize, along with two others, who helped identify 'Nitric Oxide'. Several other Doctors and Scientists, have also continued research on this over the years.

Basically (and I do mean basic) This compound or whatever Nitric Oxide is officialy described as, is only beneficial, when one breaths through the nose. As the air which carries oxygen through the Nasal passage, and the Synus, is the most efficient, if not the only means of receiving it.

Nitric Oxcide seems to have some 'Causal' properties, and effects, which is very good for our Immune Systems. I have also read that it features, in the treatment of Covid, in some Material way.. The exact details on this, I am, not ashamed to admit, are too complex for my 'Baby,Bear Brain', to absorb, and articulate.

Thus, the reason for this 'Post':

Is there anyone ou there, who has heard of Niric Oxide, or done any research on this subject, as well as nose breathing being beneficial to the 'Immune System'

I am aware that the Internet is swamped with people trying to make a Commercial Profit from, the Real Science' of this, and will try to make, as always, 'A Fast Buck'.

All the best. Ron

[AussieNeil Partner Administrator]

From a 2016 Cochrane Meta-analysis Review, specifically with respect to acute respiratory failure with low blood oxygen,

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults

ncbi.nlm.nih.gov/labs/pmc/a...

(Cochrane reviews are highly regarded)

"Acute hypoxaemic respiratory failure (AHRF) and mostly acute respiratory distress syndrome (ARDS) are critical conditions. AHRF results from several systemic conditions and is associated with high mortality and morbidity in individuals of all ages. Inhaled nitric oxide (INO) has been used to improve oxygenation, but its role remains controversial. This Cochrane review was originally published in 2003, and has been updated in 2010 and 2016."

"Authors' conclusionsEvidence is insufficient to support INO in any category of critically ill patients with AHRF. Inhaled nitric oxide results in a transient improvement in oxygenation but does not reduce mortality and may be harmful, as it seems to increase renal impairment.

Plain language summary

Use of inhaled nitric oxide in patients with acute respiratory failure with low blood oxygen does not improve survival."

Later, with respect to its effect on the immune system:-

"Nitric oxide alters immune function by modifying the release of cytokines and other components of the inflammatory cascade from alveolar macrophages (Chollet‐Martin 1996; Thomassen 1997); it inhibits active adhesion molecules and the neutrophil oxidative burst involved in neutrophil migration (Kubes 1991)."

Also, more generally, from Do Nitric Oxide Supplements Really Work?

"Research on nitric oxide supplements is mostly conflicting. A few studies support the benefits of it in heart health, vascular diseases, and elevated lipid levels."

medicinenet.com/do_nitric_o...

Neil

[Vindicatrix in reply to AussieNeil]

Thanks you so much for that very informative reply AussieNeil. It clarifies a lot for me. I am always suspicious of anyone, overplaying the effects of any, so called treatment. But I am fairly sure in my own mind, that the positives outweigh the negatives, regarding a healthy way to intake Oxygen, for CLL'rs.

Any other benefit, is a bonus. I am also a believer in the concept of, 'If it makes you feel good, it's probably doing you good, Such as, 'Snorting 'Coke' etc. All the very best.Ron

[Vindicatrix in reply to Vindicatrix]

Revise my last line, NOT Snorting Coke' . I really have to switch the brain button on, before I press send. Ron

[cllady01 Former Volunteer]

For the purpose of your last statement, "I am aware that the Internet is swamped with people trying to make a Commercial Profit from, the Real Science' of this, and will try to make, as always, 'A Fast Buck'.", it is helpful if you can post a link to what you have been reading.

I hope you have saved the URLs of pages you have read online and can provide that for us.

[Vindicatrix in reply to cllady01]

I'm afraid all I can say is, if you do a Google search, I suspect you would get enough information about it there. From the replies to the post, I have received so far, I am happy to continue my nose breathing, as I think it is beneficial on serveral levels, for me. I'm sure people will make up their on minds up. All the best. Ron

[Annie1920 in reply to Vindicatrix]

Yoga teaches that nose breathing is good.. But it's a very long stretch from good to curative or even preventative

[Vindicatrix in reply to Annie1920]

I do appreciate that Annie1920, but any little bit of good, it may, have, is another weapon in our fight, and well being. Everyone can choose their own, Action Plan'. Thanks for the input, Ron

[PaulaS Volunteer]

Hi Vindicatrix,

About nose breathing - a few weeks ago a doctor was talking on BBC Radio 4, about ways to avoid Covid infections.

He said nose breathing is safer than mouth breathing. As air passes through the nose, harmful things get filtered out and neutralized, so they don’t reach the lungs. He mentioned other benefits to health too, that I’ve forgotten.

This doctor wasn’t selling anything and his words made sense to me, though I forgot about it until today when I read your post.

Paula

[Big_Dee in reply to PaulaS]

Hello PaulaS

Makes sense to me. I have had a postnasal drip all my life, resulting in my breathing mostly through my mouth when I sleep. I have been doing morning and nightly gargles with salt/baking soda solution since having chemo treatment, which was recommended by doctors for mouth sores. I think this reduces the amount of bacteria and viruses in mouth. There have been several articles about some mouth washes limiting covid viruses.

[PaulaS Volunteer in reply to Big_Dee]

Yes, I'm sure mouth washes help. Nasal sprays are another option, both to clean and possibly add antiseptics, but I'm not sure of the science on that.

[Vindicatrix in reply to PaulaS]

I'm glad it jogged your memory. Taking everything, I have learned so far, I am an avid fan, and believer, in the benefts of Nose Breathing (Inhale/Exhale.It personally works for me, and seems to have tangible effects, so I am happy to follow this route. I do appreciate that everyone will find there own pathway to well being. I wish you well, in your endeavours. Ron

[MN1999]

I don't have any info on the nitric oxide but find it interesting. The 'nose breathing' is another fascinating subject. My son sent me, "Breath, The new science of a lost art" by James Nestor and that made me aware of the consequences of mouth breathing. A good read.

[Vindicatrix in reply to MN1999]

I too have read the book, and enjoyed it, so much that I wanted to research it further.. James Nestor has made a very good living indeed, out of this, as have very many others. with Books, Videos' and the usual ' Rich and Fame' route. He is a Journalist, after all.

There does seem to be a lot of 'Cowboys' out there, who see this topic as, a very lucrative money making venture, (they are everywhere, it seem.) Good luck to them, as long as they are treaed with caution, especially amongst the vulnerable.

All the very best. Ron

[Sewster]

I thought that book by Nestor was interesting

[Smakwater]

Vindicatrix,

Interesting however,

Kinetic energy is not conserved during an elastic collision.

JM

[Vindicatrix in reply to Smakwater]

If I knew what that was, I might agree with you Smakwater, but it's away above me I'm afraid. Thanks for replying. Ron

[Smakwater in reply to Vindicatrix]

Sorry to cause confusion, I was saying in another way that sometimes gathering the fuel burns more energy than it produces.

Although, I am always interested in seeing new or alternative ideas.

[Vindicatrix in reply to Smakwater]

Thanks Smakwater, that seems sensible, and even understandable, to my 'Baby Bear Brain, all the best. Ron

[Vindicatrix in reply to Smakwater]

I too, Smackwater, subject to reservations. Regards Ron

[Smakwater in reply to Vindicatrix]

All in a days fun right?