Pfizer vaccine response tests four months apart

[zsuzsiB]

I am participating in the LLS vaccine response study. I have CLL and I am taking Acalabrutinib. One month after my second Pfizer vaccine shot, on April 20th I had a blood test to see if I produced antibodies. The result was .48, negative. Last Friday, August 20th, I had another blood test prior to receiving the booster shot. This test, five months after my second Pfizer shot showed 1.2, positive antibodies.

Did anybody else experienced this? I thought antibodies suppose to decrease with the passage of time. I would appreciate any feedback. Thank you.

[lankisterguy Volunteer]

Hi zsuzsiB,-

You may want to submit your question to this cllsociety.org/ask-laborato...

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But I would expect that a laboratory scientist like Dr. Susan LeClair would look at the data and say that the difference is insignificant. In a test with a range from 0.9 to 250 or 2500, your two numbers are within normal variation of results.

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Whether the results will decline in a short period like 5 months or whether your body took longer than 4 weeks to reach the maximum result of vaccination would be another unknown.

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I submit that the science and data involved is far less precise than you are expecting.

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Len

[zsuzsiB in reply to lankisterguy]

Thank you Len, for your thoughtful reply. I realize that the improvement in the numbers is insignificant. Yet it is comforting to see it on the positive side, however slightly. I am curious to see what the results will be after the booster. Thank you again, Zsuzsi