Mutated p53 gene

[Tomaitch21]

Mutated p53 gene?

My dad has been told he has a mutated p53 gene (i think that’s right) and that his treatment will be either ibrutinib or another drug I can’t remember the name of at the minute.

Has anyone any advice/information about this treatment and what to expect? Is it different from chemotherapy?

The doctor said treatment would be based on funding, so which option would be better?

Thanks

[Shepherd777]

When treatment is required, which may be in a year or ten years or even more depending on his blood work and symptoms. Chemo generally does not work with TP53. Now presently they would probably start him on Imbruvica. TP53 was harder to treat years ago, but not now with non-chemo treatments like ibrutinib.

[lankisterguy Volunteer]

Hi Tomaitch21, -

The reply from Shepherd777 is accurate. Treatment with Ibrutinib aka Imbruvica has become the most common in most countries and certainly indicated strongly for anyone with a mutated or missing P53 gene- which means that the older Chemotherapy will be ineffective.

-

A common alternative to Ibrutinib is Acalabrutinib/Calquence which works the same way with fewer side effects for some people.

-

A different class of drugs is Venetoclax / Venclexta.

-

I see you joined us in March 2021, but have not filled out your profile to let us know what country and health system your dad is using, so we have been assuming USA, and the "funding" issue would be getting approval from your health insurance.

-

Len

[mja511]

I am TP53 mutated and have been on Imbruvica since Dec 2015 with great success and few side effects.

[Ibru]

My husband has p53 mutation and has been on ibrutinib for going on 8 years. Doing very well.