CLL responses to Pfizer’s Covid vaccines. - CLL Support

CLL Support

22,366 members38,474 posts

CLL responses to Pfizer’s Covid vaccines.

Twin21 profile image
5 Replies

Just sharing an ASH medical journal study of CLL patient’s responses to the Pfizer Covid vaccine:

Among patients with chronic lymphocytic leukemia (CLL, n = 169) who received two doses of the Pfizer-BioNTech vaccine, the antibody response rate was 39.5% as measured by the Elecsys Anti-SARS-CoV-2 assay at a median of 15 days after the second dose. Compared to age- and sex-matched controls, the response rate among patients with CLL was significantly reduced (aOR =0.01). The response rate was highest in patients who were in remission after treatment (79.2%), followed by 55.2% in treatment-naïve and 16% in patients undergoing treatment at the time of vaccination. In patients treated with either Bruton tyrosine kinase inhibitors or venetoclax with or without anti-CD20 antibody, response rates were low (16.0% and 13.6%, respectively):

ashpublications.org/blood/a...

Written by
Twin21 profile image
Twin21
To view profiles and participate in discussions please or .
Read more about...
5 Replies
Jacksc06 profile image
Jacksc06

Thanks for the info.

devonrr profile image
devonrr

Interesting but only a small study. In June/July we should have the report from the Birmingham study.

Although we yearn to know the effects of all the vaccines, it’s all a bit too soon.

bennevisplace profile image
bennevisplace

Thanks for posting this again. See also healthunlocked.com/cllsuppo...

To date this study from Tel Aviv is the reference for anyone interested in how CLL patients respond to vaccination against Covid19. It's the only one to yield grouped results for CLL patients at different stages of disease and treatment. The researchers plan to look at cellular immune responses too.

My hunch is that this study is essentially right and that larger studies ongoing in the US and the UK will just add more detail.

Big_Dee profile image
Big_Dee

Hello Twin21

Great info, maybe some light at the end of the tunnel for those in or working to remission. Blessings.

michaeledward profile image
michaeledward

I'm not sure of the reliability of these results. However, I am part of the CLL / Ibrutinib study at NIH and I intend to ask my NIH doctors about the effectiveness of the Phizer vaccine for those like me who have CLL. My next appointment at NIH is in early July. I'll post here whatever information they provide me.

You may also like...

Negative IgG antibodies from 1st shot of Pfizer’s Covid Vaccine

T cell antibodies to the Covid vaccines. Some background - My twin sister who is 53 had a CLL...

Positive Covid Vaccine Antibody Response

heard of non responses. Wondering if anyone has had a positive covid vaccine response. Would be...

Cll and covid vaccine uk

any light about the covid vaccine that is now available in the UK in regards to CLL my dad who is...

CLL and covid vaccines

should get a vaccine because there has really been no tests that she's aware of on CLL patients to...

Are you a vaccinated CLL patient who got covid infection anyway?

told me that CLL patients are more seriously affected by covid infections and that the vaccines...