Dose 3 of BNT162b2 vaccine stimulated humoral immune response among patients with LM, in particular patients with MM (who had higher anti-S baseline titer after dose 2) and those with no anti-CD20 treatment history within a year. T-cell response was increased among patients in particular with no active chemotherapy regimen. Our data support the use of an early third vaccine
dose among immunocompromised patients followed for LM though some of them will still have vaccine failure"
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JIDD
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This is another piece of the jigsaw puzzle. The authors admit its limitations, but do endorse booster shots for blood cancer patients overall. The effect on cellular response was, if anything, more marked than on humoral response.
This is not the first study to find no response in patients treated with a CD20 mAb less than 12 months previously (Tel Aviv did too, for spike antibody level).
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