Positive Covid Vaccine Antibody Response

[Davidcara]

Have heard of non responses. Wondering if anyone has had a positive covid vaccine response. Would be helpful to know if on WW, what type of treatment, and which vaccine.

[JigFettler Volunteer]

Help me understand. what is a NON response?

And what is a positive response?

Jig

[Davidcara in reply to JigFettler]

A non response means you got the vaccine, a few weeks afterwards you had a test to check for antibodies ( spike antibody test ). A non response means no antibodies were detected. A positive response means antibodies were detected. Non response = not good. Positive response = good.

[JigFettler Volunteer in reply to Davidcara]

Ahhh! That option of antibody check not routinely on offer pre and post vacc.

[Robbie_W]

I am concerned about that too. I had one of the pneumonia vaccines a while back and I did not produce any antibodies.

[Davidcara in reply to Robbie_W]

Since CLL affects are respond to vaccines, this is not surprising.

[Davidcara in reply to Davidcara]

Even though antibodies were not detected you still good get some help / benefit from the vaccine. But detecting antibodies is always better.

[SofiaDeo in reply to Robbie_W]

You also might get some stimulation of T cells, which is something we don't often test. So we may or may not get some protection that way, and we probably won't know if we do.

[LeoPa in reply to SofiaDeo]

newyorker.com/magazine/2021...

And the Sputnik vaccine seems to do just that. The second shot. Which is different from the first one.

[bennevisplace in reply to LeoPa]

Yes, if I may paraphrase, Sputnik V is different in using different vector viruses for the first and second shots, with a view to stimulating a more robust immune response. In UK scientists are testing the idea of using different vaccines in first and second shots, for the same reason and also to give more flexibility wrt vaccine supply.

[LeoPa in reply to bennevisplace]

Imagine how many Russian lives were saved due to not fooling around and starting the vaccination ASAP. Countless. Were there risks, sure. Did it pay off? Most assuredly.

[LeoPa in reply to LeoPa]

I hope I get the Sputnik. I like the Russian approach. The scientists took 2 weeks to make a vaccine and vaccinated themselves straight away😁. That's what I call conviction. No nonsense, go for the jugular.

[bennevisplace in reply to LeoPa]

Yeah, not sure your metaphor would appeal to recipients of that other Russian innovation, Novichok 😨

[LeoPa in reply to bennevisplace]

I'm sure the Corona virus would not like novichok either 😂

[JigFettler Volunteer in reply to Robbie_W]

Same with me. I had another pneumovax vacc shot. And no further antibody test. Did not make sense.

[Eliotf in reply to Robbie_W]

Robbie,I too had both pneumonia shots. I don't know about the antibodies, but I did get a slight case of pneumonia. I have almost no lymphocytes due to being on Venetoclax. I will tell you that we did not know I had pneumonia until about 1 month after the symptoms were gone, I had a CT scan. The CT scan showed some density in the lungs. I knew something was wrong, but it was mild enough that I did not go to the hospital.My pneumonia symptoms were mild so I never went to the doctor.

On the Covid19 - I had posted on another site: If each of these vaccines words a bit differently, then what about getting a shot of each vaccine. The response was there is already a study for that.

Reminder that the vaccines are to reduce the severity of the symptoms, not eliminate it.

[keepfit123]

I had both the pneumonia vaccines at the correct time slots and still went down with pneumonia mid January 2020!

[PaulaS Volunteer in reply to keepfit123]

Sadly no vaccines are 100 per cent effective, even for people without CLL. And there are different strains of pneumonia. The current pneumonia jabs only give protection from certain bacteria strains, not all and not viral pneumonia.

[keepfit123 in reply to PaulaS]

Does that mean there there are no vaccines for Viral pneumonia? Have you just got to fight it, even with a reduced immune system.

[SofiaDeo in reply to keepfit123]

That is correct..... the common cold adenoviruses change so rapidly, it's pretty impossible to make a vaccine for all of them. And influenza vaccine is a "scientific guess" as to which strains will be predominant in any upcoming year. The thing is, we can't just vaccinate Everyone against Every Potential Strain. There are some risks involved in vaccines, like every other medicine. Too many people could react, and likely would, if we kept vaccinating and vaccinating and vaccinating for every single strain of adenovirus, or influenza virus. We target what we choose to give. Things like measles, mumps, rubella, smallpox, polio......those diseases cause a great deal of morbidity and mortality if one gets a severe case of it. Colds and influenza are generally milder....please note I said "generally", because everyone is different. And IMO the rate of influenza has been historically high because people haven't been willing to inconvenience themselves using basic hygiene measures and infection control practices, it's an "inconvenience" because we haven't been taught starting at an early age....it's not currently a cultural norm like brushing teeth, bathing, etc. Add that to a culture where people are encouraged to come to work or school sick, or at least not discouraged to stay home until better, and it becomes a problem.

[AussieNeil Partner Administrator in reply to SofiaDeo]

Australia didn't have a flu season last year. Flu cases dropped to record low levels when Australia entered its first and only national lock-down towards the end of March, which is when flu cases typically begin to rise as we enter our flu season in autumn. Social distancing, coughing into your elbow or better still, wearing a mask and frequent hand washing, really does reduce the flu infection and mortality rate!

Neil

[JigFettler Volunteer in reply to AussieNeil]

Minimal flu in uk too. Jig

[Peggy4 in reply to AussieNeil]

I was talking about that yesterday to my daughter. Just generally in a ‘normal’ year I would have many chest infections. This year very few. It just goes to show.Peggy

[PaulaS Volunteer in reply to SofiaDeo]

Very true, SofiaDeo but keepfit123 was asking about vaccines for viral pneumonia, not viral flu. As far as I know, there are no vaccinations for viral pneumonia as such, nor for fungal pneumonia.

However, I believe many viral pneumonias originate from an initial flu infection, so having flu jabs would give some protection against viral pneumonia as well.

Paula

[SofiaDeo in reply to PaulaS]

You're right, I could have simply said we don't have vaccines for the most common causes of viral pneumonia like Respiratory Syncytial Virus(RSV), common cold adenoviruses, and influenza viruses. I went on to answer a question that hadn't been asked.....😂😂😂 guess the lockdown isolation is affecting me more than I realized haha

[Big_Dee in reply to SofiaDeo]

Hello SofiaDeo

I am not sure we will ever get to the point of overcoming things like virus and bacteria. I strongly lean to the Behavioral Sink theory.

[stevesmith1964]

At day 10 post vaccination I have no Detectable IgG Neutralising antibodies to the Spike protein. I will check again at day 14 and day 21,

[Tsadams in reply to stevesmith1964]

What vaccine, after what dose (1st , 2nd etc), wait period, did you test? I was advised, test 1 month after 2nd dose (UK, Oxford\AZ, 1st dose last week, 2nd in April.

[stevesmith1964 in reply to Tsadams]

AZ vaccine, I would expect a detectable response after 14 days, even a minor one. But I doubt it, but will know on Wednesday which is day 14 after first dose.

[Tsadams in reply to stevesmith1964]

Steve, ok, will be interested to know outcome, hope it's good. My Haemo advised do after 2nd dose, like you, was keen to know if any response after 1st.

[stevesmith1964 in reply to Tsadams]

Will let you know.... remind me on Thursday

[JigFettler Volunteer in reply to stevesmith1964]

Hi! Are you in the UK? Jig

[stevesmith1964 in reply to JigFettler]

Yes

[JigFettler Volunteer in reply to JigFettler]

Pls PM or reply here how you get it, NHS or private. Thnks

[Fran57 in reply to JigFettler]

Hello Steve.Yes, please let us know. My question right at the start was, will my husband get a good response to the vaccine ( he has his first tomorrow), because otherwise we still have to shield until covid has gone!

Thanks. Hoping you (and everyone) get a good response.

Stay safe,

Fran 😉

[JigFettler Volunteer in reply to Fran57]

I think stevesmith1964 knows there is an increasing queue for this information.

Not wanting this to get into partisan debates - It would help us CLLers to know. Just possibly we could exert some development in this area to our advantage.

Jig

[Davidcara in reply to stevesmith1964]

Thanks for the reply Steve. Are you in treatment?

[stevesmith1964 in reply to Davidcara]

Yes. Was diagnosed in November, age 56, stage 4. Went straight to treatment Obinutuzumab and Ibrutinib.

[Davidcara in reply to stevesmith1964]

Thanks for getting back to me Steve

[CrazyDaisy68]

Is it easy to request and get a spike test, do you know? I felt really dreadful for days after my vaccine and would like to know if it has at least created antibodies.....

[stewie in reply to CrazyDaisy68]

Hello , what test to do you mean ? A blood test to see what anti bodies you have produced ?All the best

Stewie

[stewie in reply to CrazyDaisy68]

Hi Daisy sorry re read the posts , the test to see if any response to the covid vaccination , not routinely offered by our consultants but have a word with your consultant they may do it , you might have to push it though , there are a lot of studies going on asking for CLL volunteers who have had the vaccination they want to study the responses , there is one near me at the Birmingham university. Please bear in mind that cll can be a very individual disease some may got better responses than others also it may require the second vaccination to get that response in some . Best wishes

Stewie

[CrazyDaisy68]

Many thanks!