Antibody Therapy vs Vaccine

[gardening-girl]

With AstraZeneca's announcement today of positive high-level results from an interim analysis of clinical trials of their vaccine candidate AZD1222, I felt compelled to post the picture above that highlights the differences between vaccines and antibody therapy. Antibody therapy is not a vaccine and should not be referred to as such.

AstraZeneca now has late-stage candidates in both categories. AZD1222 is an adenovirus vector vaccine candidate (astrazeneca.com/media-centr... and AZD7442 is a monoclonal therapy (astrazeneca.com/media-centr.... This may lead to confusion when discussing them on this forum so it will be important to specify which AstraZeneca product is being discussed.

I've added just a few of the antibody therapy and vaccine candidates to the figure. There are plenty more in the pipeline around the world!

The figure is from vumc.org/viiii/spotlight/an...

gardening-girl

P.S. Although not shown in this diagram, the antibody therapy may eventually be approved for prophylactic use.

[lankisterguy Volunteer]

Fantastic explanation and graphics. Thanks for finding and sharing that info gardening-girl Len

[Justasheet1]

Wow, really great and simple explanation. I agree with Len. Thanks GG.

[bennevisplace]

Thanks for this g-g, and here is a good source on Covid19 drug and vaccine candidates genengnews.com/covid-19-can...

Informative, if not always up to date.

It's a big field.

FRONT RUNNERS include the Gamalea, Pfizer, Moderna and Oxford/ AZ vaccines.

DEFINITELY MAYBE includes the AZD7442 antibody, phase 3 trial now recruiting, as well as some erstwhile candidates that already bombed.

If you click on a drug/ vaccine of interest and scroll down, you can select candidates categorised by VAX, RNA (incl vaxes), ANTIBODY and ANTIVIRAL.

[gardening-girl in reply to bennevisplace]

bennevisplace, I'm excited and dizzy from trying to navigate the GEN site!😩 An almost overwhelming amount of info there! I've bookmarked the site and will be checking it frequently. Thanks very much for the link!

[bennevisplace in reply to gardening-girl]

Glad to add to your stack of reading! I always appreciate your very well informed input.

[cllady01 Former Volunteer]

G-G (thanks for that appropriate shortening, bennevisplace . Also THANK YOU both for this most informative and fantastic thread contents.

[Fran57]

Thanks so much for that information and explanations.Stay safe,

Fran 😉

[wmay13241]

For immuno-compromised people who receive repeated IVIG due to low immunoglobulins, l think the mRNA vaccines offer the best chance to be effective for a long period of time.

[Hoffy]

Thanks!!