Osteoporosis caused by Imbruvica

[ettie18]

Hi everyone: I was wondering if anyone has been told that taking Imbruvica resulted in osteoporosis. My oncologist has made this connection. I have been taking Imbruvica 420 for two years and now I am beginning Forteo injections. Many thanks. Be well. Ettie

[GMa27]

I had osteoporosis before my CLL dx. Didn't take Ibrutinb but had chemo. I did the Forteo shots 2011-13. It was wonderful and worked! Make sure you take a bisphosphonate or the Prolia shots after you stop Forteo. I didn't take anything for years after and then my dexa scan numbers were showing I had gone from osteopenia back to osteoporosis. Back on my Actonel pills. May try Forteo again.

Good luck! Hope it works for you! 💕

[SunnyCA]

This is very interesting. I have been on Ibrutinib for 3 plus years and did have chemo as well years prior. Recently I had a bone density test and was kinda shocked to hear I was osteoporosis as I workout 6 days a week with weight bearing exercises. I’m going to look into this further.

[ettie18 in reply to SunnyCA]

Thank you for your reply. I had a PET CT last year which was okay and another just recently which revealed many fractures. I am still taking Imbruvica. Take good care.

[ettie18 in reply to SunnyCA]

I have a similar experience. Thank you for your reply. I hope the Forteo helps. Take good care.

[fapumpkin]

There has been much research showing an increased risk of compressed fractures in People on long periods of watch and wait who have CLL.

[ettie18 in reply to fapumpkin]

Thank you so much for your reply. I will research this. Be well.

[fapumpkin in reply to ettie18]

I have had three different treatments along with balloon khaplasty on 3 vertebrae, I was diagnosed with 11 compressed fracture vertebrae & severe osteoporosis of the the spine after 6 months of extreme pain, I had no accident or falls or any history indicating that at the age of 51 for this to happen. At the same time my haematologist said I needed to start treatment, I am on an uk clinical trial where I am being treated with ibrutinib. I am now being treated Forteo. I was on watch and wait for 9 years before the fractures. At the time of starting treatment 4 years ago I was found to be vitamin D deficient.

I have posted some of the links before:

acponline.org/system/files/...

ashpublications.org/blood/a...