I have been taking Imbruvica for five months and my blood counts, while not good, have remained staple. I had Afib prior to starting Imbruvica but it has worsen over the last month, causing 4 shocks from my Defibrillator/Pacemaker in a two week period. As a result, my Oncologist wants to take me off Imbruvica. My Cardiologist has prescribed Sotalol (a high end beta blocker) to control the Afib and Flutter. He says that my type of arrhythmia is common for elderly people and he sees no reason to stop my Imbruvica medicine, since the combination of the beta blocker and my Defibrillator, will correct any unusual heart activity. I now have to make the decision as to whether continue Imbruvica or try a more potent chemo drip for my CLL like Rituxan, or a combination of Rituxan with Bendamustine, which have a long list of other side effects. Any advice?