Hi
What treatment are they receiving for Richter syndrome?
I have only been given the R-CHOP.
Hi
What treatment are they receiving for Richter syndrome?
I have only been given the R-CHOP.
First R-CHOP and then possibly a hematopoietic stem cell transplant. Specifically, an allogeneic stem cell transplant if the patient is deemed fit enough or an autologous stem cell transplant if not. Some patients are elderly and not fit enough for either one, so clinical trials might be considered.
CLL Society has discuss some new richters trials that have done well.
CLLSociety.org
I hope all goes well,
Hoffy
I wrote a post recently about a trial combination that is being explored for Richter’s as well as for relapsed/refractory CLL. You can read the summary of the report that was delivered to the ASH2019 conference here although I’m not sure how relevant it is to you in your particular situation:
Consider a transplant if you are in a deep remission. A few promising trials.
That is one approach. The other is to do the transplant while in remission to consolidate it. If you do relapse, it can be hard to get the RT controlled again for the transplant so that is why some docs are aggressive. Look at the ASCO abstract on RT and transplant I just posted on our website. But you may never relapse or do great with a second therapy or trial. No certain answers. RT trials are promising.
I have Richter’s large B-cell lymphoma—a mass in my colon. I had half my colon removed an then 2 1/2 weeks later started 6 cycles of R-EPOCH. At cycle 4 they have added 10 days Venetoclax. The first Venetoclax was a gradual blued up. This cycle I’m taking 400mg for 10 days with chemo. (5 days) after. I’m in hospital for 24 hour continuous infusion for 5 days.
The last 2 cycles I’ve had neutropenia fever and had to come back to hospital for antibiotics.
Why didn't you get the RCHOP on the front line?
My doctors thought the R-EPOCH best
Two doctors from two different hospitals took me. Those of Toulouse where I live, they told me that with the R-Chop it was enough because they didn't find masses in my body. At the hospital where I was being treated for LLC, they told me to wear the R-EPOCH. In the end they treated me with the R-CHOP.
How are you now?
Am in middle of 5 cycle. I am weak the week after when my numbers drop. The last 2 times I had neutropenia fever. The last time lasted longest, but I think that was from adding Venetoclax.
When my numbers return, I feel good. I’m hoping we timed this one right to feel good Christmas Day.
I read the following due to the recent post by Sarasotapaul six days ago.
healio.com/hematology-oncol...
Addl support:
clinicaltrials.gov/ct2/show...
clinicaltrials.gov/ct2/show...
cancernetwork.com/leukemia-...
Sarasotapaul's Post :