Struggleing

[haposwald]

Ok I will show latest blood results 7 months on imbrutinib fist 3/4 months were absolutely fantastic! Now 7 month in and wbc down to 31k but fatigue has returned triple fold and truly just don’t feel well ruled out a virus and a little worried hematologist states could just be my body adjusting to new nearer normals any thoughts would be appreciated! Blood results below

Wbc 31.6

Absol nuetru 10523

Abs lymph 19497

Abs mono 1201

Abs eos. 190

Abs Baso 190

Globulin 1.7

A/g ratio 2.6

Thanks in advance

[Jm954 Administrator]

Your results aren’t bad at all and the only thing that is slightly unusual is that your neutrophils are towards the upper end of normal. It may indicate a sub clinical infection and that could explain why you feel below par but other tests would be needed. More discussion with your Dr is probably needed.

Hope this resolves for you soon.

Jackie

[JigFettler Volunteer in reply to Jm954]

Hi Jackie - do we have a US to UK "numbers" conversion formula - I need to brush up my interpretive skills! Many thanks Jig

[Jm954 Administrator in reply to JigFettler]

It's about moving the decimal point around and adding up in this case!

[JigFettler Volunteer in reply to Jm954]

...like 3 spaces to the left? J

[Jm954 Administrator in reply to JigFettler]

Yep! but not all of them

[haposwald in reply to Jm954]

Jackie, I’m aware that number have been steadily improving, during flair wbc was up to 497k, hoping that I’d feel much better when down to 31k. I’ve been reading about MRD. Does it apply in CLL and is there truly such a thing as CR in cll

[Jm954 Administrator in reply to haposwald]

Yes, lots of patients achieve CR but a CR and having undetectable MRD are two different things. A CR is having no enlarged LNs, spleen or liver and an essentially normal blood count.

Table 4 on page 8 of this reference gives more information: multiplemyeloma.bloodjourna... We are unlikely to reach undetectable MRD on Ibruitnib, although a few patients have been reported. It's almost exclusively seen with FCR and venetoclax combination therapy and the degree of MRD detection depends on if it's 1/1,000 or 10,000 or even more.

Jackie

[BeckyLUSA]

Fatigue is one of the listed side effects of Ibrutinib.

BeckyL USA

[haposwald in reply to BeckyLUSA]

I mm quite aware but from out of the blue isn’t like my normal fatigue diagnosed 8/8

[duffymcgrif in reply to BeckyLUSA]

Have your thyroid checked. I experienced extreme fatigue that I couldn't believe it. However, my family Dr. suggested a Thyroid test and yep, after many years, I went from medication of 110 mg a day on my Synthroid med to 125. WHAT A DIFFERENCE. So, maybe something like that could be your problem. Good Luck

[haposwald in reply to duffymcgrif]

That’s awesome I will have to give the thyroid a checkout! With my numbers closing in on normal it’d be nice if it were something easy to diagnose like that thanks so much!

[duffymcgrif in reply to haposwald]

Your quite welcome. Hopefully that will solve your problem and good luck.