NUREX - 2127 ONE YEAR ANNIVERSARY STARTING CYCLE 14

[steve5441]

Here's an update of my second clinical trial. I started this BTK degraeder November 11, 2021, now here I am, over a year later and doing really well. Other than neutropenia, and having to get a monthly neulasta injection, my blood counts have continued trending to normal levels. Here are my starting and current blood levels; Hg 8.9 14.2 WBC 2.5 6.1 Abs Neut .9 4.0 Abs Lymp 8.0 2.1 Plat 85 135 Igg 420 1050.

My doctors are pretty excited over this drug and there will be a presentation next month on Nurex at the hematologist convention.

At over thirteen years since diagnosis, and working on my fifth treatment, here's a list of my various treatments.

1. FCR 2010 all 6 cycles. 5 1/2 years remission

2. Ibrutinib 3 years developed C-481 resistance

3. Venetoclax 18 months never really worked for me, didn't like hospital ramp-up

4. Loxo-305 20 months CR then I developed a mutation that worked it's way around the drug. My favorite treatment.

5. NX-2127 12 months and counting.

[Hidden]

Hadn't heard of this one, glad there's yet another potential option!

And glad you are doing well on it! Congrats!

[steve5441 in reply to Hidden]

Thanks.

[CycleWonder]

I just started a trial for Pitrobrutinib for treatment naive patients. I was hoping not to develop resistance.

Glad to hear the new medication is working so well.

[steve5441 in reply to CycleWonder]

You will do fine on this drug. It took me 6 months and I was in remission.

[Stamphappy in reply to CycleWonder]

Wishing you all the best, CycleWonder. Hope all goes well and for a long remission.

[steve5441 in reply to Stamphappy]

Thank you.

[BobbyFour]

That is a very encouraging result!

[cllady01 Former Volunteer]

Here is the clinical trial info: clinicaltrials.gov/ct2/show...

Great news, Steve, and thank you for sharing.

[steve5441 in reply to cllady01]

Thanks for volunteering your time

[Smakwater]

Results appear to be promising steve5441.

looks like the trial is only in the UK?

Thank You for all of your trial participation.

JM

[Smakwater in reply to Smakwater]

Actually found US locations at this link - clinicaltrials.gov/ct2/show...

[steve5441 in reply to Smakwater]

I don't think this trial had a bunch of slots available. Thanks

[Smakwater in reply to steve5441]

All I could read is that there were 130 participants estimated for enrollment, and that recruiting is still active. Most likely is dependent on the individual hosting institution.

[steve5441 in reply to Smakwater]

Thank you

[Big_Dee]

Hello steve5441

That is really good news, blessings.

[steve5441 in reply to Big_Dee]

Thank you.

[200185]

So glad you’re doing well. Keep on trucking

[Stamphappy]

Steve5441, thank you for your post. I first read about Nurex - 2127 last Fall. I've been following it online since.

Sounds like you are doing well on this trial 👏 I'm so happy for you!! Thank you from the bottom of my heart for your participation. So nice to read this positive news. Just wanted to wish you all the best. Please keep us posted.

[steve5441 in reply to Stamphappy]

Thank you so much.

[alpek]

Glad you are doing well it sounds like a promising trial, have you had any side effects to the medication?

[steve5441 in reply to alpek]

So far just the neutropenia. Monthly injections of neuprogen keep it in range.

[Katinlr]

Congrats on your success Steve and thanks for being a part of a trial which may help many of us. Do you know what type of resistance mutation you developed to the LOXO?

[steve5441 in reply to Katinlr]

Yes, and my Dr told me about it last week at my visit, but I don't know if they had assigned a name to it as of yet. The researchers at MSKCC isolated and identified the mutation. The discovery actually came from one of my many blood samples.

[Thundercat2]

I had not heard of this one either but always glad for more options. Please keep us posted on your progress. We appreciate you!

[steve5441 in reply to Thundercat2]

Thank you.

[Doremefasol]

Hi Steve, I am so happy for you that you are doing well. I am finishing Venetoclax in August. I know from my doctor, they will have the trial that you are on now. Could you tell me, please, if you had any mutations confirmed by testing at the beginning of your treatments? Just when you started your first treatment. I always worry, because, I have TP53.