I just got the results of 2 new tests back. One is called an Oncoplex Cancer Gene Panel and the results said : “The sample tested is positive for copy loss of portions of chromosome 5
(includes CD74 and RPS14) and a low level variant in ASLX1 “
I trie to look this up, but was confused by the article I found. Can anyone explain this to me?
Also, perhaps I have living with blinders on, but it was only when the other test confirmed B cell lymphoma, Non-Hodgkins Lymphoma, that I figured out that CLL is one of the 6 main sunsets of Non-Hodgkins.
This test confirms that the b-cell destroyer Venetoclax and Rituximab is the best protocol for me!
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t2aa
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t2aa, Reading about del5q, I could not find many articles relating it to CLL, but it did seem that having less of CD74 and RPS14 could be a good thing. In one case it was even suggested that anti-CD74 antibody might be a good therapeutic strategy for CLL!
In the case of CD74:
- “CLL cells overexpress both CD74 and its ligand MIF in comparison to healthy B cells.”
- “The surface receptor CD74 has been shown to be an important regulator of B cell survival.”
- “…blocking of CD74 or its ligand MIF, e.g. with an antagonistic anti-CD74 antibody, might inhibit survival of CLL cells and their homing to the bone marrow."
Dissertation Title: Function of the CD74 receptor in B cell pro-survival signaling in the context of chronic lymphocytic leukemia
Thanks for your reply. Those were the articles I was trying to interpret. I was worried it meant I have myeloid cancer as well, but I have none of those symptoms so that must not be right.
I see my team on Monday when I ramp up to the full dose of Venetoclax. I don’t know when I see my actual doctor next.
I think I’ll email him for answers.
The ramp up is going remarkably well. My lab results are pretty great so far and I feel better than I have in months.
I think that since these genes have been spotted while researching CML or MDS could certainly increase one's anxiety. But it could be that they were originally found during CML/MDS research, and now that there are these genetic tests, we can see they happen in CLL, too.
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