Experiences with

Bendamustine

Diagnosed for CLL in 1995. 2013 : Leukeran + Rituximab In 2021 I received only 1 cycle of Bendamustine (90) + Rituximab. No further cycles because of hemolyse. 2024 Now possibly Venetoclax + ? Appointment with oncologist next friday. Not much of a help. Best regards, Dick

[/i] Of note is the optional inclusion of Bendamustine for debulking* and the MRD guided protocol [i] "All patients received the MRD-guided triple combination, and 18 received optional debulking with bendamustine prior to induction, which consisted of six 28-day cycles of the triple combination and

I was testing with low dose again with imbruvica at 140 mg I changed Doctors they did a Bone marrow Biopsy and determined that I am a notch 1 mutation and because of the original treatment of Bendamustine developed. MDS.

Those older chemoimmunotherapy treatments, typically Bendamustine + Rituximab (BR) or Fludarabine + Cyclophosphamide + Rituximab (FCR), selected for tougher to treat sub-clones, which they cause through inducing DNA damage that will hopefully trigger apoptosis [u]if[/u] the TP53 gene isn't mutated or

I had 6 month first line treatment with bendamustin and rithoximab in 2022 september ended. .when i start my treatment my numbers was very high wbc 146 rbc was low in 2022 janeuary the numbers was wbc126 rbc 3.23 hgb 10.9 plt 135 LDh 920. because of high in ldh one of recent doctor said may be

Subsequent treatments (the next 4 months) were bendamustine and rituximab intravenous drips. No problems at all. The prognosis for bendamustine isn't as good as fludarabine - the likely effective period being 4 or 5 years as opposed to 15 years for fludarabine, but thats life.

I did Bendamustine and Rituxan. After my first treatment I was put in the hospital for a high temperature and very low wbc’s and neutrophils. I also had an allergic reaction to the Allupurinol they give you before chemo. They cut my bendamustine dose in half after that.

Prior to the advent of targeted therapies, we only had chemoimmunotherapy treatments, typically BR (bendamustine+rituximab) or a very old drug chlorambucil to offer to most patients needing treatment.

I can't see any justification for Bendamustine+Rituximab (BR) treatment when targeted therapies are available. You don't see this curative effect with BR.

She is taking Bendamustine monotherapy and was in remission about 3 years after treatment. Now she has one enlarged lymphnode in her armpit, her hematologist said that CLL is slowly coming back. Leukocites 7.7 Lymphocites 52% Everything else in her lab results and ultrasound is fine.

Findings from SEQUOIA showed that at a median follow-up of 25.0 months, the median progression-free survival (PFS) was not reached (95% CI, not estimable [NE]–NE) with zanubrutinib vs 33.7 months (95% CI, 28.1-NE) with bendamustine and rituximab (Rituxan; BR) in patients with treatment-naïve CLL/SLL

This application was based on earlier findings from an interim analysis of the ALPINE study along with phase 3 findings from the SEQUOIA study (NCT03336333), which showed improvements in PFS compared with bendamustine plus rituximab (Rituxan).

Hi everyone, My father has CLL/SLL from 2018 and had his first treatment at 2019 with Bendamustine and Rituximab because of very enlarged lymph nodes. After his treatment the lymph nodes decreaded to the original size.

1st week after 1st treatment of bendamustine. Is diarrhea normal side effect? Seems like a stomach bug but stool is oily. Thanks for help

In these two trials, BRUKINSA demonstrated superior efficacy versus either bendamustine plus rituximab (B+R) or ibrutinib in first-line or R/R CLL, respectively.

More info here:https://www.cancertherapyadvisor.com/home/cancer-topics/chronic-lymphocytic-leukemia/zanubrutinib-bests-bendamustine-rituximab-cll-sll-previously-untreated/

There was a time almost a decade ago that I was severely neutropenic from Bendamustine, so I'm not complaining about my high ANC, just wondering what my cause.

hi all after use bendamustine my numbers went down but unfortunately i got civid what should i do please help me thanks for sharing your thoughts

Hello, I am a 66 year old male, CLL for about 10 years, was in W &W until Feb, 2021, then completed 6 months treatment with Bendamustine and Rituximab in July 2021, two follow up appts. since then both went well with MRD at 0.07%. I had a Infusaport (port) placed for my treatment.

on Calquence for CLL, he's had Chemo at least three times over about 15 years, Bad reactions to Rituxan, weird skin issues, looked like tick bullseye rings that started on the upper torso traveled down his body, down his arms and legs and then disappeared, he was in remission after the last chemo...Bendamustine