I am writing this to document what I am going through and maybe compare with others experiences with FCR treatment for CLL. Intro: USA Male Diagnosed 2 years ago (age 50) with routine CBC labs and small swollen lymph nodes. CLL recently went from slow to rapid growth (Last 6 months). Hemo Dr. decided clinically it was time to treat before I had major symptoms. I agreed. Because of my age the Hemo Dr. decided FCR would get me the best outcome for the longest period of the time in remission. I have read up on this and decided ok. Started First FCR Cycle last Wednesday and Day 1 was rough. I went into Chemo shock with the Rituxan drug FC drugs went ok. It scared the heck out of me but the nursing staff handled it well and they stated this happens to most patients on their first cycle. I wasn't sure about that but I made it through it. Day 2 and 3 were the FC drugs and I tolerated it ok. Day 3 also included the neutrophils auto injector system. Yesterday, I was wiped out tired not sure if it was from the chemo or the neutrophils or maybe both? Today, I am at work and experiencing the typical tiredness with headaches that everyone reads about. I have an office job so getting through the work day ok. My question is do the FCR cycles get easier or stay the same or worst as the more I do of them? The nursing staff states most people have some symptoms after each cycle but they claim the recovery time is faster. I am not sure to believe them or not. I guess we will see. Cycle 2 in mid Dec 2018. There will be some anxiety about Rituxan Day 1 of Cycle 2.