My husband's CLL numbers are still quite low (he was diagnosed this past July, unmutated IgVH, otherwise unexceptionable), but his immune system has been compromised in odd ways. About six weeks ago, he had either a bug bite or an allergic reaction that has caused lesions all over his arms, legs and trunk. He's been treated with antivirals, antibiotics, anti-itch creams and prednisone, which has been quite effective. However, every time they try to transition him off the prednisone, he gets down below 20 mg a day and the boils start popping up again (and driving him crazy with the itching). Has anyone had a similar experience? His medical team is now discussing possible gamma globulin infusion or monoclonal antibodies to get the immune system back on track and prevent further outbreaks.