has anyone ever been treated with just Bendamustine alone without a monoclonal antibody?
bendamustine: has anyone ever been treated with... - CLL Support
bendamustine
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If you’re elderly, Bendamustine is a great chemotherapy. If you’re young <70, don’t you dare use it unless you absolutely have to. It does more damage to your body than FCR.
Do you have any references to support your comment that Bendamustine as a single agent does more damage than FCR? In combination with Rituximab, BR comes out as more gentle than FCR, hence its recommendations for older patients, so I'm surprised to read your comment.
Thanks,
Neil
dsspivak, Where is the information that backs your statement? I am confused because there is nothing I can find that refers to the damage your refer to.
Bendamustine has been used as a single agent in the former Soviet Union and GDR for 50 years...
The CLL10 trial directly compared FCR to bendamustine/rituxan [BR]... you can read about it from Dr. Sharman
cll-nhl.com/2013/11/fcr-ver...
The 'does more damage statement', I have never seen referenced, in fact Bendamustine is considered less myelotoxic than FCR, from my understanding. The purine analog component isn't as powerful as fludarabine.
that`s probably why if when I need treatment again it was suggested I do R/B. FCR resulted in too much toxicity for me and I only got about 7 months out of it anyway-care not to repeat it! then I thought about getting R again and I decided I didn`t want it for the third time. lo and behold my last appt. doc said he`d give me only B which mentally I had decided for anyway since bad things always happen to me when I combine drugs. my CD 20 was "dim" %, low, on last test anyway.
well, I couldn`t stand ibrutinib- tried to do it twice, suffered crippling side effects then R/ Zydelig which put me in the hospital with pneumonitis the first month I started it. FCR was my first treatment and every side effect listed for each drug I experienced for the six months I did it and then for the next six months I was seeing a doc for all the leftover side effects and then never achieved a remission anyway. I`m 60, "healthy" and 13q14 IGHV1-69`01 family, mutation rate 0%. As Dr. Hamblin once put it I`m in the "middle bucket" Why is Bendamustine o.k. for elderly-will they die from the treatment anyway or did they run out of options? I looked at side effects for B and they`re about equal to the other alkylating agents out there. I`m hoping the "formula a chemist friend gave me continues to work-the only side effect I experience is my taste and smell are "off" at times. In fact, so many cancer cells flooded my blood stream yet my blood count stayed normal that my ONC asked me to come in and when he saw I looked good-had no sweats, fever, or huge lymph swelling he told me he`d just watch my blood work for next month or two. (Of course, I didn`t tell him what I was taking) When he asked me if I was still using O2(from my zydelig encounter) I said when I jump on the trampoline or take a good long walk, he said, you jump on a trampoline? I said yeah, why, shouldn`t I? oh, no, that`s good!, he said. I still muse about his amazement.
I used Bendamustine with out any Rituxian. I did that for 6 mo. Had a 3year remission. Now I am on Imbruvica and doing well.
good, I hope this will happen to me eventually!
Only once a month. But my question for you is why has your Doc decided to put you on that and not on Imbruvica ?
how many days in a month did you get Bendamustine? As for ibrutinib I couldn`t tolerate it. I`m not doing B yet as I am still W&W.
Just once every 28 days. It did give me 3 yrs of remission. You could try Ventocolax.