My first round of BR went fine with no change in liver numbers. My ALT and AST are usually under 20. Three days after my second round they were slightly over 20, 5 days after the second round they were close to 40, and 10 days after the second round (today) they are over 100, which concerns me.
Has anyone else had an experience like this?
Rich,
Mine did that too. It’ll normalize before you get to do it again.
Jeff
Did it happen the second time but not the first?
I just checked and mine took off after round 3. Round 1 and 2 were normal.
Thanks. Same kind of pattern. We seem to becoming friends. I know a lot about ibrutinib and acalbrutinib, if you have any questions.
Rich
Rich,
My liver enzymes went up but at the time, I was in a blind clinical trial. The thinking was that the idelalisib was causing it but it turned out I was on a placebo and BR. My LDH was always high/normal too. Everything was entirely resolved about a month after treatment ended.
I’ll pick your brain on the 2 BTK’s pretty soon. I’ll be on one or the other fairly soon.
Jeff
Like I said, I strongly recommend acalabrutinib.
By the way did yours go up slowly like mine? I did not hit a really high value until today.
Got it. Problem is, it’s not approved for CLL right now and the only way you can get it is either through a clinical trial or having major issues with ibrutinib and then asking your doctor to fight your insurance company to cover it.
One member of this group got it for first treatment by having his doctor make a case to his insurance company. You should at least try that. I got it as second line (I plan to only do BR twice and then acalabrutinib) when imbruvica landed me in the hospital.
Did you see me question above about your time progression?
They noticed it right away on my third round of treatment. They held the placebo/idelalisib thinking that would normalize it but it did it on its own.
So it did not go up gradually over a week or so like mine? How high did it go?
The ALT went to 99 and then 236 at round two. Then returned to normal. I was told that the liver was filtering everything out and the anti nausea meds plus the prophylactic meds were elevating them.
Wow, How long after treatment did it take to get to 236? Did you possibly have hepatitis?
It went there in one month and was almost normal the next. It was during treatment.
Thanks. By the way I think you meant round 3 above, not round 2.
Treatment of My Father suffering from CLL with Endoxan (Cyclophosphamide) and Bendit--Bendamustine Hydrochloride.
Round 2 FCR complete
FCR and nausea
