My father has CLL and has been on ibrutinib for about 6 months. He noticed some swelling in his wrist/forearm a few weeks ago. He had a doplar and all is clear. A few days ago his hand and forearm really started to swell. He saw his GP who is sending him for another doplar - and also left a message for his oncologist. Is anyone aware of this being a side effect of ibrutinib- if so- what is the recommended course of action?