I just had my three month check up. My doctor informed me of some new and upcoming treatments. I thought I would share:
There are several new treatments that are available for the treatment of CLL. In addition to the standard chemo-immunotherapy combinations of the past (These are regimens like Fludarabine-Cytoxan-Rituxan and Bendamustine-Rituxan) there are also newer anti-CD20 monoclonal antibodies with a drug called Gazyva (obinutuzumab). There are three “newer” oral targeted drugs for CLL therapy. Ibrutinib and Idelalisib have been out for a few years and help to block different areas of the b-cell receptor. The newest FDA approved medication (approved in April) is venetoclax which targets a protein called BCL-2 (This drug is not used up-front at this time as it is only FDA approved for people with a 17 p deletion). So there remains several newer options for the treatment of CLL.
These medications are typically used as single agent by themselves. (Idelalisib (Zydelig )is actually FDA approved in conjunction with 8 doses of Rituxan). Obinutuzumab is an injection which runs over about 4-6 hours.
Have any of you tried these treatments?
I hope everyone is taking care of themselves!