I was diagnosed with CLL 15 years ago at age 49. Four years later I developed a Richter's transformation (Hodgkins) that was successfully treated. My early experience with Ibrutinib was nothing short of miraculous. The palpable nodes in my neck and axillae shrank dramatically. As expected, my white count rose precipitously, but has gradually declined over the past two years until most recently. Over the past 3 months it has risen from 25k to 44k with 90% clonality, i.e. CLL cells. There does not appear to be any enlargement of my nodes and I feel fine. I realize that I am, relatively speaking, an early user of Ibrutinib, but I was wondering if any others have experienced a significant rise in their WBC after 2 years of decline and what if anything is an appropriate way to address it? Thanks for your response.