"Dr. Vallera and colleagues enrolled 25 chemo-refractory patients with previously treated pre-B acute lymphoblastic leukemia, chronic lymphocytic leukemia, or non-Hodgkin lymphoma whose tumors expressed CD19 and/or CD22. Eight patients had previously undergone unsuccessful bone marrow transplantations. Patients had a median of three prior therapies and their median age was 55 years.
Two of the 10 patients who could be evaluated had durable objective responses, with one complete remission after two cycles of therapy.
All patients received a single cycle of the immunotoxin therapy at varying doses between 40 and 80 µg/kg administered as four intravenous infusions for 2 hours every other day.
The most common adverse events were low albumin, weight gain, transaminitis, and fever. These events were transient and were generally grade 1 or 2 in the patients treated at higher doses (≥ 40 µg/kg per day).
Two patients had a dose-limiting toxicity with the 40- and 60-µg/kg doses.
The patient who achieved complete remission had relapsed CD19-positive, CD22-positive diffuse large B-cell lymphoma and was treated with the 60-µg/kg dose."
These were tough to treat patients.
Photo: We've had some very strong winds this past year, bringing down many trees, which in turn can bring down farm fences. This tree amazingly dropped on a dropper (the steel fence post) and embedded itself sufficiently to stay stuck there when the tree was sawn up.