Approval of Imbruvica Frontline for 17p deleted CLL and Important Trials

[bkoffman]

Hi Friends,

The recent approval of ibrutinib for 17p deletion frontline hopefully is the opening wedge of more indications for treatment naive patients for it and other non-chemo choices.

I have posted why this is so important and a list with links to some important clinical trials on my latest blog post bkoffman.blogspot.com

Thanks. Stay strong

Brian

bkoffman.blogspot.com

[Ernest2]

Many thanks Brian for a great post on the blog, to give an introduction to 17p and function of the p53 gene, and front-line trials for 17p deleted.

I've been wondering for a while what has happened to front-line trials in the USA of all the new options, so that neatly answers that question.

Hopefully that success prompts getting more of those trials started & completed elsewhere around the planet.

International challenge: Would be good if those in the know for different countries could post a simple summary of status in that country for considering/completing front-line trials, and include separately both 17p deleted and normal patients, also other key groups.

Very Best Regards,

Ernest

[bkoffman CLL CURE Hero in reply to Ernest2]

I believe there is a British trial now for ibrutinib frontline.

[Olgun16 in reply to bkoffman]

Thank you Brian for your tireless support for fellow CLL sufferers through your blog and contributions to Patient Power. I was first treated with FCR some 6 years ago and have now relapsed. ( my P 53 is fine, I am told) I am taking part in clinical trials at Kings College London, UK. One involves Bandamustine plus novel antibody. The other therapy involved is Ibrutinib. I am waiting for written details to enable me to make an informed decision. Obviously I would like to avoid chemotherapy option but opting for Ibrutinib will involve a lot of tests like bone marrow extraction etc. So I am a little anxious about making the right choice.

Good wishes,

Olgun

[Cllcanada Top Poster CURE Hero in reply to bkoffman]

There are two in the UK as far as I'm aware... iceCLLe... a small trial looking at how Imbruvica (ibrutinib) works and FLAIR... Imbruvica (ibrutinib) and Rituxan in treatment firstline...there may be more...

ukctg.nihr.ac.uk/trialdetai...

ukctg.nihr.ac.uk/trialdetai...

In Canada there are a number of trials for Zydelig (idelalisib) pending, one is with rituxan for 17p deleted first line...

[Hidden]

I'll second all of that!

It's really a bit silly and a bit tragic that they are having to do additional trials for front line use. We already have that data -- from me. And the other treatment naive lab rats whom MD Anderson insisted on including in the original Phase 1b/2 trial. I believe there were 18 of us and we're probably all still taking it now 3 years later.

Yes, it works just fine.