British Liver Trust
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Liver enzymes

Has anyone ever had " normal " AST & ALT blood work after years of not and still have Cirrhosis ? For some reason my blood work is showing all in the normal range except for platelets which are low and the Eosinophils are high, both all the time. I had Hepatitis C which caused Cirrhosis, I took the medications and they stopped the Hepatitis C last year. But now I can't breathe right and this Doctor says I may potentially have Cirrhosis , ok I was diagnosed F-4 with severe fibrosis / Necroinflammation ACT Grade 3 severe activity just wondering how did I get to potentially in a week ?


6 Replies

Hi, I really don't know enough about this to help you. Hopefully, someone else on here will be able to offer more advice. My gut response was that if you have had cirrhosis in the past, it is likely to still be there, or some of it. I know the liver is very good at repairing itself, but I don't know if past cirrhosis can all go. Also, I don't understand why not breathing properly is the link to potential cirrhosis.

I think it would be best if you contact the trained advisors at the 'British Liver Trust' ... 'BLT'. They host this site on 'Health Unlocked', and there is a link to their website at the top of this page. There you will find info on email and phone links to talk to someone. I think it may be better to talk to someone with more training, and also someone with all sorts of links and contacts at their fingertips. Above all try not to worry and stress, which is always the worst for these sorts of conditions. Take some immediate positive action, as well as trying to spoil yourself as a boost. Maybe even phone the Doctor and tell him your worries and queries - we never think of all these things at the time

Sorry if this seems feeble, but I hope it helps, meanwhile take care and treat yourself!




Your medical history is quite complex. It really would be a good idea to discuss your medical queries and concerns with your GP and liver specialists who can accuraetly advise you and know you best.

If you are having problems with your breathing and are concerned, then you should be seen immediately by a doctor, or if out of hours, your nearest accident and emergency department in hospital.

Best wishes,




I think you meant to send that to Dldtx, who posted the question. It's come to me - GrittyReads instead. Though I agree with what you say, and realise I should have said that as well/instead.

Thanks for all your work, you are all brilliant.


Thank you :)


Yes it is, I have totally discussed any and all of my conditions with several dr's and specialists, the reason I ask a question here is that several people if not all have experience some of the same issues along with other conditions. I currently am in what call the "poke you mode" where every doctor has a needle with my name on it.


My husband has normal ALT & AST, only his Monocytes & Basophils are out of range and he definitely has cirrhosis. He was listed for transplant but delisted again as his blood tests returned to normal levels taking him out of the criteria for transplant.

As I understand it F4 on the Matavir scoring chart is Cirrhosis, once you have it then that's it, cirrhosis doesn't go away. It is now thought that if the causal factor (in your case HEP C) is treated and is no longer attacking the liver it can reverse a little but it won't go away completely.

If you are now suffering breathing issues you really need to see a doctor - your liver doctor preferably - for further tests as cirrhosis can lead to lung and breathing problems such as Hepato Pulmonary Syndrome.

Best wishes


What Does My METAVIR Score Mean?

The Metavir score grades the degree of fibrosis on a 5-point scale from 0 to 4.

The activity, which is the amount of inflammation (specifically, the intensity of necro-inflammatory lesions), is graded on a 4-point scale from A0 to A3.

Fibrosis score:

F0 = no fibrosis

F1 = portal fibrosis without septa

F2 = portal fibrosis with few septa

F3 = numerous septa without cirrhosis

F4 = cirrhosis

Activity score:

A0 = no activity

A1 = mild activity

A2 = moderate activity

A3 = severe activity


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