to have second prolia ? Nervous

[Bonehealt]

I have had one (first and only ) prolia injection in August this year . For the first time in 3,5 months - the back pain has subsided and I feel a little more human. Jaw sore ?

Does this mean that my body has adjusted and will handle the 2 prolia injection better ?

Or will the second injection be accumulative . Ie will the pain increase as there is now shot 1 ( effects) and then shot 2 effects in the body ?

The doc says prolia is best for high fracture risk although t score only -2,5

I am leaning toward relaying off with Boniva

Doc says dental effects worse with Boniva

( had implant and jaw work prior to starting any of these drugs )

Question is will affects get easier or worse with second prolia injection ?

[MayGodBlessYou]

i don't know but my Mum basically had no issue with prolia for 3 years and now has considerable problems, so if it were me, i would look for something else, including a new doctor. good you find out now. i would run with my life. look for something else and have prolia last on the list. take care.

[Bonehealt in reply to MayGodBlessYou]

I appreciate your kindness. Wishing mom well

[Arcadia10]

I wouldn't say that you're at high fracture risk if your T-score in one area is borderline osteopenia/osteoporosis. Is that your hip or your spine and what is the T-score in the other area scanned? Have you calculated your FRAX score (fracture risk) frax.shef.ac.uk/FRAX/tool.a... ? That is very useful to give you your risk profile. Presumably you haven't had any fractures to date as you don't mention them.

Prolia is designed for post-menopausal women at high risk of fracture for whom no other osteoporosis medication has worked (eg. an oral bisphosphonate like Fosamax). If you're not in that category, you should think long and hard about having a second injection, the reason being that once you've had the second injection, you cannot cease Prolia without relaying to a bisphosphonate for at least 2 years. The risk of rebound fractures post Prolia is significant, affecting 10-15% of people. Boniva is not an efficacious relay medication, from what I understand.

Regarding the cumulative side effects - Prolia seems to affect different people differently. I had 4 injections before stopping. The first one was fine, no problems. I felt really ill about a month after the second one - very groggy and spaced out, had diarrhea and lost 3kg. Unfortunately I was travelling overseas at the time and didn't make the connection to the Prolia injection a month earlier, just thinking it was mild food poisoning. The further side effects when I returned home (muscle/shoulder pain for two months, then sore throat for the next two months) continued until about 4 weeks before the next injection. The third injection didn't seem to cause any side effects beyond the ongoing feeling of being unwell/spaced out but the fourth one really floored me. I had three bouts of bladder pain/urinary frequency in quick succession although no infection as such was found. Then I ended up going to ED with severe chest pain, vomiting and not being able to get out of bed for two days on my return home, and finally ended up with a swollen red rash on my upper eyelids and eyebrows and cheek. Finally after 18 months of dragging myself around feeling ill, a new GP said I was allergic to Prolia and should stop having the injections - which I did. I transitioned to an inefficacious bisphosphonate (Actonel) on the advice of an ignorant doctor and ended up fracturing both sides of my sacrum, pelvis and two ribs.

I'm not saying that this will happen to you, but just be very careful that you know what you might be getting yourself into if you have a second injection. You can safely stop after one injection, but not two. The fact that you've had implants is also cause for concern as several people on this site have lost their implants as Prolia affects the blood supply to the jaw. Your doctor should have made you aware of this, but I've found that dentists actually know more about the side effects of Prolia than doctors do, so speak to your dentist as well.

My advice to you would be not to mess with this drug unless you really need to.