My daughter, 6, presented with posterior uvietis and chorioretinitis. It was discovered during a routine eye exam. She, throughout the years has also had bouts of diarrhea/constipation, reoccurring numerous mouth sores, reoccurring but less in number vaginal sores, moderate skin rashes as well as intermittent and nagging joint pains. All of which i brought up to her docs but even I didn't connect at the time. She went through all the blood tests and the doctors HAD diagnosed her with Behcet's. The steroids that she was on (prednisone 5mg/kg, 5ml/day) relieved her of symptoms. At a month of being off she had another flare which included all the symptoms above as well as her eye. Her rheumy ordered a blood test to check for inflammation levels throughout her body. It came back normal. The Uvietis Clinic (opthal. + rheumy) decided to remove the Behcet's diagnosis due to that result as well as her not having the genetic markers. That confused me b/c from what I've read, they are not conclusive enough to rule in or out a diagnosis. Anyhow, they keep talking about methotrexate but the hesitation is they don't have a conclusive dx to what is causing all of these symptoms. This time around, the steroids have helped relieve all the symptoms except the eye inflammation. Her mouth sores while on the meds, haven't lasted more than 24hrs. So getting them swabbed has proved a pain. NOW, they are suggesting an eye biopsy to help them narrow down possible dx. I have been given some time to think about it. Has anyone here or your loved ones had a biopsy performed for their eye lesions? Obviously I'm nervous about risks and am trying to weigh the pros vs. the cons. What are your thoughts? ? Please, feedback is much appreciated!! Thank you in advance.