by sca3

[xiaoduoyu]

Friends, I want to ask you a question. After consulting your previous replies and information, I saw trehalose. I tried to take trehalose orally for nearly a week and found that I did have gastrointestinal discomfort, always farting and diarrhea. I want to know if there is any solution to this

[CardiCorgi]

You can try mannitol instead of trehalose. Molecularly it is almost the same, and some people have less trouble with mannitol. Mannitol does not have any research related to SCA3, but it does have significant research related to Parkinson's and autophagy. Autophagy is the process your body uses to clean out cellular debris and is at the heart of what trehalose MIGHT be doing in the body. You can use the search function here and find enormous amounts of information on mannitol. As for trehalose, I had the same trouble, but after about 6 months the trouble stopped. I would just say that IF . . . and it is a BIG IF . . . but if trehalose can actually help slow progression of symptoms for people with SCA3, I, personally, consider the side effects a small price to pay.

[wobblybee in reply to CardiCorgi]

Mannitol is a diuretic that is used to reduce swelling and pressure inside the eye or around the brain. Mannitol is also used to help your body produce more urine. This medicine is used in people with kidney failure, to remove excess water and toxins from the body.

[xiaoduoyu in reply to CardiCorgi]

Hello, thank you for your reply. All the patients I know say that eating trehalose and medicinal trehalose are different, with different molecular formulas. But I firmly believe that eating trehalose also has an effect on us. It may be very small, but it can also achieve the effect of placebo

[wobblybee]

Mannitol is an approved osmotic diuretic used to treat increased pressure within the skull. There are side effects and risks. It can have the effect of drawing water from the intestinal wall. Taking in too much water can cause diarrhea, abdominal pain, and gas. It has also been associated with heart failure, electrolyte abnormalities, and low blood volume.

parkinsonsdisease.net/resea...

At doses up to 50 g, trehalose is safe for human, and no symptom has been reported in the majority of subjects except trehalose-deficient individuals in whom; gastrointestinal side effects may occur. In animal studies, no deaths were observed following intravenous administration, though diarrhea sporadically occurred. Trehalose is absorbed similarly to that of glucose by either the oral or intravenous administration

ncbi.nlm.nih.gov/pmc/articl...