TUDCA Study Summary

[bluejadedwho]

I am posting again about TUDCA, as out all of the possible treatments, I have the most faith in it.

This study: sci-hub.hkvisa.net/10.1007/...

It talks specifically about ALD.

In order to help those without a science background understand it better, I have used ChatGPT to summarize the study, and then to rewrite it so that one without a science background can understand it easier. The following is the simpler summary of the study:

"The paper is about a disease called X-linked adrenoleukodystrophy (X-ALD), which is a rare and serious condition that affects the nervous system and the adrenal glands. People with this disease have a problem with breaking down certain types of fats, which then build up and cause damage, especially to the brain and nerves.

Scientists in this study are looking at a particular process in the cells called the unfolded protein response (UPR). Normally, the UPR helps cells deal with stress by fixing or getting rid of proteins that aren't folded properly (proteins need to be folded into the right shape to work correctly). But in some diseases, like X-ALD, this process doesn't work right and can actually cause harm.

The researchers found that in X-ALD, this UPR process is turned on too much, which can lead to more problems, like nerve damage. They also discovered that a substance called tauroursodeoxycholic acid (TUDCA), which is a kind of bile acid (a component of bile, which helps digest fats), can help calm down this overactive UPR. In mice that have a disease similar to X-ALD, TUDCA helped protect the nerves and improved movement problems.

So, the big takeaway is that TUDCA might be a helpful treatment for people with X-ALD because it can help stop the damage caused by the UPR being too active. This is a big deal because there aren't many treatments for this disease right now."

[Yevgenii]

Thank you very much for doing research and making comprehensive post! I also have faith in this supplement. But I think to see any difference we have to take it for a long time, since processes in mice go really fast they show improvements earlier. In our case process can take months or even years. I'm not sure about dosage for TUDCA, in research papers it was different. For ALS it was 2g and for Multiple Sclerosis 1g.

Please, keep posting. I think it may give a hope for other patients also.

By the way I decided to make my own research and found that TUDCA may lower cholesterol (some drugs lowering cholesterol were effective in lowering VLCFA), increase glutathione levels (this element was deficient in brains of people with ALD). Also taking into account that TUDCA can cross blood-brain barrier I guess it may really improve our condition.

[bluejadedwho in reply to Yevgenii]

I will! I have been researching for over 20 years, and with the new help of the AI ChatGPT, it is makes researching so much easier and more efficient.

I agree that is it something that we need to stick with in order to see any changes or results. I am guilty of not sticking to something, as I want to see noticeable changes quickly, and often jump to the next thing to try. I am now set on taking the TUDCA. I am doing 2g/day. I have also added a great quality algae to my regiment. (Spirulina and Chlorella). I was taking so many different supplements, and taking this covers everything the body needs except for Vitamin D. And along with TUDCA and helping with glutathione levels, it contains glutathione itself.

Not to be too graphic, but since taking it, I am going a lot, and it definitely doing a detox. It is capable of chelating heavy metals from the body, and these days, pretty much everyone is overloaded with them. I mean, who knows how much of this disease is related to that, or can be helped by ridding the body of these toxic elements?

If you do decided to try the algae as well, be careful as some products actually contain heavy metals themselves (the cheaper ones). Also, some companies use high heat to dry them, which kills a lot of the nutrients.

And that is a great and interesting observation about cholesterol!

[Yevgenii in reply to bluejadedwho]

Algae is good. But I heard that it may contain BMAA toxin that may lead to ALS, since it may damage neurones. Please consider it before taking it.

[bluejadedwho in reply to Yevgenii]

Through research and contacting the company I use, I’ve been informed this is not present as long as the source is from good quality. It’s important that it’s growing in tanks and not in the ocean for example.

thanks though!

[wilburlois15]

Thanks for this!

I tried it before and ended when I started the MIN-102 trial. When that ends, if it ever does, I'll be back on TUDCA again.