Starting Nubeqa and taking Atorvastatin 80 mg. Should he decrease the dose of atorvastatin?

[Sunshades]

I have been reading here that some have had increased liver enzymes on Nubeqa and statin drugs. My husband is stopping Abiraterone and prednisone and starting Nubeqa because of increased liver enzymes. He has had a bad reaction after stopping the prednisone 5 mg a day, decreasing to 2.5 mg a day and then stopping prednisone altogether, so restarted 2.5 mg a day.

Now I’ve read here that some have elevated liver enzymes on statins and Nubeqa! So I’m wondering if he has to be careful about taking Nubeqa and Atorvastatin 80 mg.

[Laun]

yes. I use only 10mg crestor now. Or change drug. Read the Nubeqa brochure. It increases crestors effect.

[Sunshades in reply to Laun]

Thanks, he’s starting it Wednesday. I’ll ask the doctor about this

[AlvinSD in reply to Sunshades]

Definitely discuss with his doctor before he starts. The Nubeqa prescribing information has specific interaction information about the statins listed in the picture.

Nubeqa package insert pic

[Professorgary]

research curcumin, magnesium and berberine to mitigate the side effects of adt. Curcumin cleanses the liver and increases kidney function as well as controls bp and glucose. Berberine lowers lipids and glucose. Magnesium for bp and heart health. Many suffer from edema, the berberine will take care of that. I just added berberine about two months ago and my nonfasting glucose dropped from 120 to 140 range to 99. As always, discuss with doctor first. I got to stop hctz because berberine is a natural diuretic. Berberine also is good for gut health. Please note I never suggested you take these, only research and then make your own decision after discussing with your doctor. God bless.

[podsart]

I just started nubeqa and was told to reduce my crestor to 5mg, as both meds share the same pathway. Pharm said they found this impact magnified crestor 5x

Check w pharm to see if your Lipitor also shares the same pathway

[j-o-h-n]

to Sunshades,

You raised a good question about "statins" that I will have to ask my M.O. and my Cardiologist asap. I've been taking statins before using Nubeqa and am currently still taking Nubeqa. "The story is "what's the story guys?" and do I have to pay them or pay you for the consultation?

Thanks for the info and now please update your patient's bio (and stay out of the sun).

Good Luck, Good Health and Good Humor.

j-o-h-n

[Sunshades in reply to j-o-h-n]

Ok thanks. I’ll get to the bio soon

[Healer73]

hi, just finished research with my GU Med. Onc. and Cardiologist. With Nubeqa you should Not be on a Statin. The only acceptable Stain is Pravastatin and only 10 mg at that. When you combine Nubeqa and 10 mg of Pravastatin you get a total of 20mg. This is the maximum for a Statin. Hope this helps.

[Sunshades in reply to Healer73]

Yes, thank you very much!

[VictoryPC]

Ask a real Specialist as it will affect Nubeqas effectiveness. You want it to work forever.

[Sunshades]

I’m contacting the cardiologist tomorrow

[mysammy]

I know taking Crestor is more potent with Nubeqa and the dose needs to be adjusted Not sure about other statins

[Azores1]

what about Repatha with Nubeqa?

[Sunshades]

I’ll ask the cardiologist

[bigiron]

Go to Drugs.com and check all your drug interactions. Nubeqa increases the potency of statins.

[Sunshades]

the cardiologist stopped the Atorvastatin and started zetia. He will check the lipid profile in a month and if necessary add another non statin drug ( I forget the name of it)

[Fonske in reply to Sunshades]

drugs.com says:

What is bempedoic acid?

Bempedoic acid (brand name Nexletol) is an oral, non-statin, LDL cholesterol-lowering treatment that may be used in adults to:

lower the risk of heart attack and heart procedures (for example stent placement or bypass surgery), in those unable to take recommended statin treatment (a cholesterol-lowering medicine), or are not taking a statin, who:

have known heart disease, or

are at high risk for heart disease but without known heart disease.

reduce low-density lipoprotein (LDL, or bad cholesterol) in those with high blood cholesterol levels (called primary hyperlipidemia), including a type of high blood cholesterol called heterozygous familial hypercholesterolemia (HeFH).

Bempedoic acid should be used along with diet and other cholesterol-lowering medicines, or alone if use with other cholesterol-lowering medicines is not possible.

Bempedoic acid lowers LDL-C levels in the blood and works by blocking an enzyme called adenosine triphosphate-citrate lyase (ACL) that is involved in the production of cholesterol by the liver.

Bempedoic acid was first FDA-approved on February 21, 2020, under the brand name, Nexletol. There is no Nexletol generic.

[Sunshades in reply to Fonske]

Yes! That’s the drug he would add in a month if his lipid profile shows he needs it

[Sunshades]

and after all of this research because he might start taking Nubeqa and then I found out that actually Abiraterone is metabolized in the liver by the same enzyme that metabolized Atorvastatin and Atorvastatin 80 mg a day by itself can affect the liver. So it might have been playing a role in elevated liver enzymes already