Is stopping zytiga and 5 mg prednisone cold turkey safe?

Liver enzymes AST and ALT from one lab was 150

Ish on April 29, 2019 . This was taken with GP for unrelated cancer care. Today , AST and ALT were both in the 40s . MO said to stop zytiga (1000 mg) and prednisone for one week . After one week , go back to zytiga of 1000 mg and 5 mg of prednisone.

From all I have read , prednisone needs to be tapered of .

What would be best? Listen to MO and not worry about tapering off zytiga???

[Tall_Allen]

A week probably won't do any damage - ask your MO if he thinks you have to taper off the prednisone.

[Hidden in reply to Tall_Allen]

MO is hard to get a hold off . I told the MO that I read it was dangerous to stop taking prednisone cold turkey . His response was I am taking a low dosage (5 mg) right now and it was only stopping for one week I should be okay.

With that conversation do you think it would be fine to stop prednisone for one week ?

[Tall_Allen in reply to Hidden]

I agree that the dose is very small and that in a week, little would occur. By the time a week has passed you will be re-starting anyway.

[tango65]

At difference of other people in this group, I don't have any clinical experience with patients taking zytiga and prednisone for more than 2 months and stopping both without tapering the prednisone. These 2 links have some information about discontinuing exogenous steroids and about discontinuing zytiga and prednisone.

ncbi.nlm.nih.gov/books/NBK2...

ncbi.nlm.nih.gov/pmc/articl...

[RalphieJr64]

I stopped Zytiga with no problems. Still on prednisone though with new clinical trial drugs. But you should taper off slowly if longer than a week.

[Magnus1964]

At 5 mg of Prednisone I don't think there is any problem.

[jdm3]

I was advised to taper the prednisone. One tablet every other day for a week. Then one half tablet every other day for a couple weeks... or something like that

[SatuitMike in reply to jdm3]

Just did the exact same thing in preparation for Xtandi.

[GoBucks]

MO is being very conservative. ALT & AST in the 40's is not that big a deal. 41 & 40 are the high end of normal. You MUST discontinue if your numbers are 5 time greater than normal. I went to the 190's before stopping. Once my #'s returned to normal I went on 1/2 dose of Zytiga & then 3/4. I've stayed there for months.

[Hidden in reply to GoBucks]

When you stopped your zytiga , did you stop prednisone too?

[GoBucks in reply to Hidden]

Yes.

[Hidden in reply to GoBucks]

thanks