Liver enzymes AST and ALT from one lab was 150
Ish on April 29, 2019 . This was taken with GP for unrelated cancer care. Today , AST and ALT were both in the 40s . MO said to stop zytiga (1000 mg) and prednisone for one week . After one week , go back to zytiga of 1000 mg and 5 mg of prednisone.
From all I have read , prednisone needs to be tapered of .
What would be best? Listen to MO and not worry about tapering off zytiga???
A week probably won't do any damage - ask your MO if he thinks you have to taper off the prednisone.
MO is hard to get a hold off . I told the MO that I read it was dangerous to stop taking prednisone cold turkey . His response was I am taking a low dosage (5 mg) right now and it was only stopping for one week I should be okay.
With that conversation do you think it would be fine to stop prednisone for one week ?
I agree that the dose is very small and that in a week, little would occur. By the time a week has passed you will be re-starting anyway.
At difference of other people in this group, I don't have any clinical experience with patients taking zytiga and prednisone for more than 2 months and stopping both without tapering the prednisone. These 2 links have some information about discontinuing exogenous steroids and about discontinuing zytiga and prednisone.
ncbi.nlm.nih.gov/books/NBK2...
ncbi.nlm.nih.gov/pmc/articl...
I stopped Zytiga with no problems. Still on prednisone though with new clinical trial drugs. But you should taper off slowly if longer than a week.
At 5 mg of Prednisone I don't think there is any problem.
I was advised to taper the prednisone. One tablet every other day for a week. Then one half tablet every other day for a couple weeks... or something like that
Just did the exact same thing in preparation for Xtandi.
MO is being very conservative. ALT & AST in the 40's is not that big a deal. 41 & 40 are the high end of normal. You MUST discontinue if your numbers are 5 time greater than normal. I went to the 190's before stopping. Once my #'s returned to normal I went on 1/2 dose of Zytiga & then 3/4. I've stayed there for months.
Two questions for the group concerning PCa spread to lungs and also about high liver enzymes.
Zytiga and Prednisone dosage
Speech and Numbness Side Effects of Zytiga and/or Prednisone
35 Days Of Taking Zytiga With Food
Reducing zytiga dose
