daralutamide and relugolix

[podsart]

interested in the side effects of those taking daralutamide and especially those taking daralutamide together with relugolix

[Leonardo556]

I take Nubeqa 1200 mg and Orgovyx 20 mg (⅙ tablet). Nubeqa alone increases testosterone more than twice. Adding a small amount of Orgovyx brings testosterone back to baseline. So far, oncological results are promising with very few side effects.

[podsart in reply to Leonardo556]

thanks

So you cut the Nubeqa into 6 parts? It a pretty small pill. Interesting strategy.

Didn’t know Nubeqa raises testosterone.

Assume the 1/6 size orgovyx was chosen to get to a target level of testosterone. Why not take full dose Nubeqa and drive your Testosterone as far down as possible?

[dhccpa in reply to podsart]

He can answer, of course, but it may be simply that Nubeqa by itself doesn't drop actual testosterone levels. He said he wanted to get back to his baseline T, not undetectable, for whatever reason, therefore the tiny portion of Orgovyx. That's my interpretation if what he meant, but perhaps I'm mistaken.

[Leonardo556 in reply to podsart]

I tried one pill of orgovyx once every three days but the side effects of testosterone fluctuations were severe.

[podsart in reply to Leonardo556]

ok

So you didnt want to use a full dose orgovyx as the side effects would not be acceptable. This is what I am trying to assess. I am on full dose orgovyx and, of course, feel fatigued as a result. My concern is how much will the fatigue be magnified by taking full dose Nubeqa. As my wife said, she doesnt me to become a zombie.

[Teacherdude76]

Nubea, easier to spell, I am on it for the second time after a 10 month vacation. Lupron with it.For me no side effect other than as with Lupron only.

First time on Nubea was three years. Initial diagnosis was G9, aggressive in 2015.

Now at 77 this need my left hip replaced and that has my attention

Present OSA is 0.08.

[podsart in reply to Teacherdude76]

Thanks