statin for PCa BCR

[SimMartin]

Anyone shed light on whether to take a statin as it want suggested when was diagnosed with G9 localised PCa and had my RT and then 19 months of zoladex (17 months pst RT) with PSA nadir of <0.01 and testosterone of <0.5 for most of the time.

My issue I is that I had polio and si have post polio syndrome which makes me susceptible to muscle effects and aching anyway - an on reclast due to ADT aggravated osteoporosis and my paralysis and wheelchair use make exercise and definitely weight bearing more or less out of the picture.

However I’ve maintained my weight and kept most metabolic issues at bay by diet and good sense. However my lipids are ok but maybe a bit borderline and I now read that a staton can reduce likelihood of BCR particularly in high risk PCa.

The other issue is that statistically if the two type of traditional statins such as Atorvastatin or slightly less effective Rosuvastatin.as not lipophilic

However because of my particular possibly (not certain) polio muscle side effects the satin Pravastatin but it is less potent and has lower lipophilicity, so may have less direct impact on prostate tissue and so not commonly associated with anticancer effects.

My ESR is 2 and CRP remain low .for 20 years and all through ADT. My lipids have been equally stable for over 20 years at TC 5.1 ( 197.3) HDL 1.4 (54.1) DL 3.3 (127.6) Triglycerides 0.8 (71) ApoB 0.98 - so despite not having had a CAC score the statin for CV risk reduction is marginal at my age of 74 and its slight impact on immunity and BP

Any views or info would be very helpful as I unsure how to balance risk vs benefit with my polo and already very low muscle mass and mobility.

[Tall_Allen]

I take pitavastatin (4 mg) for cholesterol, which doesn't have myopathy side effects that other statins do.

[SimMartin in reply to Tall_Allen]

yes I had thought of that but that is a hydrophilic statin so would work for CV and reduce my LDL - but as it doesn’t cross the tissue boundary as water soluble its not so effective as the lipophilic statins at inhibiting PCa cell growth. Of course as I read it there is still not a lot of good quality prospective DBTs on statins and PCa but a good number of observational studies and a few meta analysis of past studies.

I should really probably have a go and monitor the side effects and if none go got it, the polio muscle issues is a risk for muscle pain but kit everyone with polio gets it - and there’s some studies that show a large number of those are nocebo effect.

[Tall_Allen in reply to SimMartin]

Statins, have little effect, if any, on PCa.

[Grandpa4]

consider calcium score. If it is 0 might not be worth it. Low dose statins rarely cause muscle issues. Might try low dose statin plus Zetia to get ldl to 75. Follow CK closely and stop if it goes up.

[SimMartin in reply to Grandpa4]

I should get a CAC score done but the price in U.K. is around $750-800 ( just CT no dye!!) as NHS won’t do it - therefore insurance won’t pay either so we are at the mercy of the health company sharks - a cardiologist told me to take a holiday on the EU and get it there as much cheaper - think it’s around $150-200 over in US ?

[SimMartin in reply to Grandpa4]

Is this an accepted fact now ? I had read that whilst no prospective or RCT there was observational studies and retrospective studies which had some of unceasing evidence and biological logic - read an overview which discussed the possibilities and evidence which seemed promising if still not well investigated

[TuffNuttoCrack]

I was told MDAnderson did a study and people who took statins did better. I don’t have any details. I was previously allergic to statins but 5 mg Rosuvastatin worked without problems. Statins help to prevent calcium from building up in your heart, a common problem with Lupron and abiraterond treatments.

[SimMartin in reply to TuffNuttoCrack]

I think they were looking at IBC ( inflammatory breast cancer)?but there have been a few studies on PCa

[Mgtd in reply to SimMartin]

Could you please list them? Thanks

[SimMartin in reply to Mgtd]

sorry for delay in response but this is one meta analysis

rdcu.be/eatfB

[Mgtd in reply to SimMartin]

Thank you!