New to group

[Bluehearts]

Hi guys just joined group,was diagnosed with prostate cancer 2021 PSA was over 1,000 had operation on spine then radiotherapy followed by chemotherapy then monthly Degarelix injections now been advised by oncologist to go onto Zoladex and Biclutamide as PSA has been slowly rising again,was down to 0.96 after chemo now 2.3.Hopefully this will help.

[RyderLake2]

Hello,

Your story sounds much like mine. High PSA at diagnosis and widespread bone metastasis. The only difference is I have never had chemotherapy. Degarelix (Firmagon) and Zoladex (Goserelin) have different mechanisms of action but they are both ADT drugs. In other words, they deprive the body of Androgen and the most common type of androgen is testosterone. The advantage of Zoladex is you only require an injection every three months as opposed to monthly and you don’t get the injection site reaction that is common to Firmagon. BTW, Firmagon or as we commonly call it “Firm is gone” is a goofy name for a drug that causes castration! 😀

Your next step will probably be an ARPI (androgen receptor pathway inhibitor) drug like Xtandi (enzalutamide) or Zytiga (abiraterone). There are many others. Normal procedure is to stay on Zoladex. Good luck!

[Bluehearts in reply to RyderLake2]

Thanks for the advice, at the moment I'm going to be on Zoladex for three months till they see how I get on with it.Cheers

[Kaliber]

welcome to the group brother. Great medical information and experience here ….along with great guys and their gals.

Hope your holiday is a nice one for you and family ( if you have some family there ).

❤️❤️❤️

[j-o-h-n]

Greetings Bluehearts,

Would you please be kind enough to update your bio. (age, location, meds, treatment center(s), doctor(s) and etc.) All info is voluntary but helps you and helps us too.

Thank you, and keep posting, this is a great site.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Tall_Allen]

A second generation hormonal agent (not bicalutamide) is SOC in cases like yours.

[Conlig1940 in reply to Tall_Allen]

Tall-Allen.

Your thoughs on the next step after .

Gleason 3 +4 = 7 rising PSA - Dec 2023 7.3 --- Oct 2024 10.0 Bone & CT Scan clear . ?

[Tall_Allen in reply to Conlig1940]

Please PM me.

[Bluehearts in reply to Tall_Allen]

Sorry Tall_Allen I'm not up with all the acronyms don't know if USA is different to England.I've just joined and it seems a lot of you guys seem to use these letters a lot so it will take me a while to get used to it.

[Tall_Allen in reply to Bluehearts]

Sorry.

SOC=standard of care.

Second generation hormonal = abiraterone or enzalutamide, which I think are approved in the UK for metastatic castration-resistant prostate cancer.

[SsgCulldelight]

Hey and WELCOME, tough battle my friend but you will win, if you haven't yet, knock off the sugar, it's feeding the good cells and they will stir sugar as fat beside s a host of other issues sugar causes. Alkaline diet is the way to go to heal your cells and reprogram them to metabolize your food more efficiently, as for nilutimide or any other androgen therapy, it works but as you know it won't cure you. A great diet and plenty of reverse osmosis water can help tremendously. Exercise a often as u can, get that heart rate up for at least 30 min not to strenuously though, don't hurt yourself. Positive affirmation give it a try. Cheers.

[JohnInTheMiddle in reply to SsgCulldelight]

Along with some good basic advice such as exercise!, any reader should however steer free of unsupported and radical claims, such as an alkaline diet, for which there is zero evidence and further because it's impossible.

[SsgCulldelight in reply to JohnInTheMiddle]

I hear u, they're is much too be said for an alkaline physiological environment concerning human and animal organisms. Our bodies are not much different than our counterparts when it comes to diet. With the super processes in our did and meats today I don't see how u could say there's zero evidence, funny doctors who not tell you that, the first thing the mention is diet change. Our system does not digest sugar, meats or processed grains well, that's a fact. Radical is is resting meat and our teeth aren't designed to rip or tear. To each their own though,

[lcfcpolo]

Welcome. UK here as well. I also had a diagnosis over 1,000 in May 2020. No chemotherapy as it was during covid. No radiation offered either. I started on one month Bicalutamide and then switched to Enzalutamide. I'm in England. If in Scotland it is Abiraterone I think. Basically Ryder and Tall Allen have given the recommendations that I would have given. Good luck my friend.