Can pumpkin seeds kill prostate cance... - Advanced Prostate...

Advanced Prostate Cancer

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Can pumpkin seeds kill prostate cancer cells?

TuffNuttoCrack profile image
60 Replies

I love em. I bought six bags three or four months ago at a big box store thinking I would have a years supply and I now have two bags left after just depleting this bag to the right. They are a good source of protein too. But you are going to get some fat with it too.

Got curious this morning about their health benefits and looked it up on the always truthful web and found this article by WebMD written January 4th, 2024. It was written by a PhD and medically reviewed by an MD so it appears to be factual.

webmd.com/diet/health-benef...

It states that laboratory studies have shown that pumpkin seeds can stop the growth of breast and prostate cancer cells and goes on to say that it may kill them by apoptosis. Some of you might also get some other unexpected really nice benefits but I’ll let the article speak to that. I’ll be dog!

In any event I eat a lot of different nuts and hopefully the kidney stones stay at bay. I had only one chemo two years ago before getting pneumonia and my four bulky lymph node tumors are about dime size today from three or four inches. Maybe that’s to be expected on a diet of Lupron depot and abiraterone. But I do think nuts have been a form of chemo for me and I eat them cause they are tasty in my yogurt strawberry blueberry banana and flax seed breakfast. Pumpkin seeds though…. you gotta eat them like popcorn apart from other stuff. I usually eat them throughout the day.

All this being said, eat these and other alleged cure cancer foods and supplements at your own risk. Drink lots of water so you don’t get stoned!

Good luck and God bless you in your fight, it’s a tough battle we face.

I researched this a little bit further Sunday evening and found a tech article supporting the general assertion. pmc.ncbi.nlm.nih.gov/articl...

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MrG68 profile image
MrG68

"It states that laboratory studies have shown that pumpkin seeds can stop the growth of breast and prostate cancer cells and goes on to say that it may kill them by apoptosis."

You know what, I'll say this with 100% confidence.

"It states that laboratory studies have shown that pumpkin seeds can stop the growth of breast and prostate cancer cells and goes on to say that it may not kill them by apoptosis."

What part of that convinces you that it's something to rely on and eat bags of pumpkin seeds?

TuffNuttoCrack profile image
TuffNuttoCrack in reply toMrG68

For educational use only as the material (the attached screenshot of WebMds article) is subject to copyright laws and conflicts with your words “May Not” as you changed them from the single word “May”. You do not want to change an authors words as that in itself a violation of copyright.

in answer to your question, the article came out a year possibly two years after I began eating pumpkin seeds. I eat them cause I like them, not ever for thinking they might have a curative purpose and I don’t intend to change how many seeds I eat because of the article. More power to them if they have some stated ability to stop growth or kill cancer cells.

A single bag contains 21 servings of a quarter cup. They are currently ten bucks a bag. When the price dropped to six bucks three months ago I bought 6 bags or four months worth of seeds if you abide by their recommended serving size.

Screenshot of WebMD article
MrG68 profile image
MrG68 in reply toTuffNuttoCrack

Copyright? 🤣🤣

For what it's worth, I didn't change the authors words. I used own. Both are equally valid. It's all good though.

I'm not saying don't eat pumpkin seeds. If you like them, go for it. I've even had a few in the past myself.You're body is ridiculously complicated. Eating pumpkin seeds may help to kill cancer cells. Bleach will also kill cancer cells, but I don't recommend you rely on any data for that either.

My point is, however, I would consider articles which have stronger data, rather than someone having a PhD.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toMrG68

Of course the question was solely rhetorical. It’s always limited data in these supposed ways to inhibit cancer growth.

If my provider said Tuff Nutt, we got a last ditch effort Moon shot for you never been tried, yeah I would sign up to put my arm in the “Mosquito chamber”. Actually some nurses told me a few months ago of a moon shot in evolving a terminal lady who brain cancer and whatever they gave her, maybe it was some type of venom… it cured her. Don’t try this on your own, it will kill you before the cancer!

MrG68 profile image
MrG68 in reply toTuffNuttoCrack

I'm not sure if this helps you or not, but I'll try.

I think people read that you can induce apoptosis by taking antixoidants. Taking antioxidants neutralizes the ROS. I'm sure if you look within the literature you'll see this in there. Probably some cancer cell line in a dish dying when some antioxidant is introduced. I don't have any reason to believe that this won't work or that the data is inaccurate.

I think its a natural reaction therefore to consider taking antioxidants, since that's what is proven in some literature somewhere by people with heads the size of planets. People will also naturally tend to lean on the heavy dosage side of the scale, to attempt to try to maximise some effect. All reasonable logical thinking to some people.

The issue for me, and I'm sure that some people don't agree, your body isn't a petri dish. Its an EXTREMELY complicated closed loop system with electrical signals, hormes, light receptors, chemicals, tempreture related, emzymes, pH, deuterium depleted water, and everything else you can think of, thrown into a thing we call a body. Also different parts of the body has a different environment. pH in one place is different from the pH in another. Your body also hosts bacteria that can be considered dangerous outside where they live!

There is all kinds of magic happening at the cell level. ONE of those things is a balance of oxidation and reduction. Introducing antixodants, will affect the balance on this and potentially cause apoptosis of the cell. But your body isn't a petri dish. You can't model what goes on your body this way. For example, introdrucing antioxidants with the intent of invoking apoptosis may actually have an adverse effect since you're effecting the balance. The truth is, you just don't know whats going on. Maybe it helps, maybe it makes it worse. What works for one person may have the opposite effect for another. Everyone is different.

These type of studies are interesting, but I just don't believe that you should be relying on them - regardless of what the results say or who has done them. They are not a representation of your body.

I'm not saying you shouldnt give it a go if you fancy it. Why not? Maybe it works for you. What I'm saying is, if pumpkin seeds were the answer, we'd all be eating pumpkin seeds and this site would be out of a job.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toMrG68

I almost missed your comment. The sponsors would be jealous, You are right, Popping a few seeds is hit or miss at the Kreb’s cycle level so best not to put all your hope in one basket.

Mgtd profile image
Mgtd in reply toMrG68

Great analysis! I would like to add my findings from a yearly study I do every year at this time. It deals with pumpkin seeds and pumpkin flesh.

Starting Oct 1 of every year due to the cost of carrots in the winter months I am able to buy pumpkins at very reasonable prices and one pumpkin last about two or three weeks of daily feeding which I supplement with about 2 cups of shelled peanuts. I feed this to my Ebert squirrels daily.

Over the last 20 years not one of the animals has had prostate cancer. So I guess that the antioxidant qualities of pumpkin flesh and seeds support their anti cancer properties.

PS They love the pumpkin and all the seeds.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toMgtd

Was it the kind vet or the overworked oncologist who performed the DRE? Your post was great and brought a smile to me!

dhccpa profile image
dhccpa in reply toMrG68

So either way pumpkin seeds stop the growth? Just uncertain whether it kills them by apoptosis? Or did I misinterpret?

MrG68 profile image
MrG68 in reply todhccpa

Yeah, I was referring to the Anti-Cancer Properties image he attached.

It says 'Researchers think that the anti cancer activity of pumpkin seeds may be due to the high level of anti oxidants...' by apoptosis.

dhccpa profile image
dhccpa in reply toMrG68

Pumpkin seeds pop up in various OTC prostate supplements, but I believe those are marketed very generally for "prostate health." I do eat them, however, alternating them with other seeds or nuts. Not cured yet, though!

MrG68 profile image
MrG68 in reply todhccpa

I think its also extremely important to realize that I could be completely wrong!

If you talk to my wife, she'll confirm thats the case a lot. 😆😆

TuffNuttoCrack profile image
TuffNuttoCrack in reply toMrG68

My wife is like a squirrel that dips into the small gasketed plastic storage container.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toTuffNuttoCrack

Taking away from my food supply. I think we are going to have to buy a few more bags since she saw the article.

dhccpa profile image
dhccpa in reply toMrG68

A wife telling her hubby he's wrong? You left out the word "always", my friend!

MrG68 profile image
MrG68 in reply todhccpa

😂

MrG68 profile image
MrG68 in reply todhccpa

But, I think its worth saying that nothing wrong with giving them a pop and see what happens... if you like pumpkin seeds 😊

TuffNuttoCrack profile image
TuffNuttoCrack in reply toMrG68

Ha ha.

London441 profile image
London441

Stop the Lupron and abiraterone and see how you do with the seeds. If the disease becomes out of control then you’ll know how well they actually work. You might have to give your life for it, but at least you’ll have given them a fair shot.

Better yet find some studies of patients with similar pathology to yours who treated with seeds only so you don’t have to guess.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toLondon441

I would be the only one in the self made double blinded randomized clinical trial due to the extreme rarity of my cancer. It would be foolish for anyone to stop their current standard of care and depend on this or any other supplement of the day.

London441 profile image
London441 in reply toTuffNuttoCrack

And there you have it.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toLondon441

It’s a reality there are few brave experimenters. We generally follow what the oncologists say.

Professorgary profile image
Professorgary in reply toLondon441

You would only know if it works for you. No treatment works for everyone. One could say Docetaxel, pluvitico, abiraterone, etc May or may not kill cancer cells in your body. It’s all a crap shoot. Pluvitico works well for 30% of patients and yet it is touted as a very effective drug. Abiraterone works well for many and yet there are some who don’t respond. Pumpkin seeds have a high amount of zinc so it may help the prostate but unlikely it will kill cancer cells but I said unlikely.

The thing that amazes me is when an incurable cancer patient given only a few months to live who has tried all SOC tries something alternative and is cured you can bet your arse the medical profession will say it was the SOC that cured them.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toProfessorgary

In my opinion a blanket SOC is not right for everyone. If it’s in their interest they will offer you something different, but I wouldn’t count on any patient suggested tweaks.

London441 profile image
London441 in reply toProfessorgary

By the same token if that one incurable patient is cured with a supplement (or is believed to be) then you can bet your arse there will be a YouTube channel and several Facebook groups claiming it to be superior to SOC.

NecessarilySo profile image
NecessarilySo

Some foods (e.g. lycopene) seem to work with Lupron, like magnifying its effectiveness in killing prostate cancer cells. The fact that your tumors have shrunk significantly is significant. I suspect that cardamom and black pepper MAY also help. Heat also helps. Stay the course.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toNecessarilySo

Thank you for your comment, I don’t know anything about cardamom but I take a 1000 mg pill of black pepper turmeric. I should rename myself Mr Retrospective.”

Just as an aside when I spent sixteen days in the hospital this past April, I was not given abiraterone the whole time…..but no pumpkin seeds either.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toNecessarilySo

Necessarily so, the interactions of all that we eat and drink can never be quantified in terms of any individual. We as you say have indications, plant based diet certain supplements but nobody really knows nor is there enough experimental work in the laboratory using experimental design to find the optimized formula of a mix of supplements, or mix of fruits and vegetables or a mix of meats or all of the optimized ratios from each category of intake variables to produce the most cancer killing power in the lab…. In my opinion our focus is solely on drugs and the other part is neglected.

32Percenter profile image
32Percenter

Tuffnut you're taking some heat for this, but I do get where you're coming from. They may help your PCa, you enjoy them, and they can be healthy in moderation and provide fiber to keep you regular. Where's the harm in it?

I feel the same way about black cumin seed oil, and I take a whopping tablespoon a day of the stuff. Studies show it can help fight off viruses and bacteria, and I went for about 10 months this year without getting sick, despite my neutrophils and other immune markers being in the toilet thanks to ADT. Studies also show an active ingredient in it (thymoquinone) has an anti-cancer effect, and can help docetaxel kill prostate cancer cells. Would I drop my SOC drugs and rely on it alone to see if it'll suppress my cancer, and risk death? Of course not! But I'll keep taking it for the health benefits, and spread the word that it MAY kill PCa cells!

Thanks for letting us know about pumpkin seeds' possible anti-cancer properties.

TuffNuttoCrack profile image
TuffNuttoCrack in reply to32Percenter

32Percenter love that part about not being sick! I’ll look it up. Thank you!

Heats no problem, my team designed and built a solar factory in nine months, no pressure like going in and talking with the CEO, who says I want to make some major architectural modifications apart from original design, or I’d like all our employees to move in a month earlier than planned.

The question was designed to provoke a good discussion.

PELHA profile image
PELHA in reply to32Percenter

I have that for my husband to take but it tastes a bit like gasoline. Any tips for consuming?

32Percenter profile image
32Percenter in reply toPELHA

It's definitely an acquired taste for sure! I've never taken it solo in the morning and then continued on with my day (I couldn't imagine that taste in my mouth for several hours), but here are my usual options:

1) Chase it with my morning protein & fruit smoothie

2) Chase it with a shot of orange juice (swig like mouthwash)

3) Eat a banana immediately afterwards

TuffNuttoCrack profile image
TuffNuttoCrack in reply toPELHA

Ok, first it seems that all pumpkin seeds are not alike. I’m a former chemist but spent most of my career chemical engineering. In your case of the seeds smelling like gasoline, they could have used a solvent in an extraction process and the odor could be from that solvent. If it smells like a solvent don’t consume them is my suggestion. You might be doing more harm than good. Also I don’t eat but a few palm of the hand single layers of seeds a day. Not even their serving size.

I’ll give you an example of toxity, I ordered a cargo liner. It came in seemed to be of thin rubber but it smelled like asphalt outgassing so something off about their process. The smell was so strong taking it out of the car after five minutes it made my car stink and the odor was hard to wash off my hands. Asphalt contains compounds which long term inhalation exposure are carcinogenic. That may went back to supplier.

I’m sorry to mislead anybody but the seeds I get from a big box store are sprouted and organic, little to no odor. The company that makes them claims the sprouting process breaks down phytic acid.

As I don’t want to be suspended for promotion you might go look at the picture I attached for any clues as to who made them.

Hint:it’s up at the top of the picture, five letters and .com and you are at their web site. All the best, Tuff Nutt.

Professorgary profile image
Professorgary in reply to32Percenter

Yea, what you said!

32Percenter profile image
32Percenter in reply to32Percenter

Here are a few quick links to research on TMQ & cancer:

pubmed.ncbi.nlm.nih.gov/281...

pmc.ncbi.nlm.nih.gov/articl...

pubmed.ncbi.nlm.nih.gov/216...

The tricky part is getting enough TMQ into the bloodstream, which is why I take a tablespoon a day of the oil (capsules won't be enough). The oil needs to have a high-TMQ content, at least 2-3%. I use Buie Black Seed Oil from Amazon (4-6%).

TuffNuttoCrack profile image
TuffNuttoCrack in reply to32Percenter

Thank you for the links you provided. I did look thru them. I’m on autopilot for next several months.

swwags profile image
swwags

Supplements like Turmeric can be dangerous to the liver. Any prescribed ADT medication for our disease can also be hard on the liver. The problem with any supplements is that we don't understand if it's contraindicated with the prescribed drugs we take. There are few if any studies available. Even as standalone, supplements are not regulated. If you take them, bring your brand to a lab and have them confirm the ingredients.

As to pumpkin seeds? Who knows. When my PSA started to rise, I was eating broccoli sprouts like nobody's business. I also took saw palmetto. Didn't even slow it down.

You can kill anything in a Petri dish. My personal take is that if research or product uses the word "May" or "Might", it doesn't work.

Here are some side effects of eating too many pumpkin seeds:

Pumpkin seeds can have side effects if eaten in large quantities or by certain groups of people, including:

Stomach discomfort

Pumpkin seeds are high in fiber, which can cause gas, bloating, constipation, stomach cramps, or diarrhea, especially if you aren't used to eating a lot of fiber.

Weight gain

Pumpkin seeds are high in calories and fat, so eating too many can lead to weight gain.

Allergic reactions

Some people may experience allergic reactions to pumpkin seeds, such as itching or rash.

Reduced mineral absorption

Pumpkin seeds contain phytic acid, which may reduce mineral absorption if consumed in large quantities.

Harm to people with low blood pressure

Pumpkin seeds are antioxidants and can help to lower blood pressure, so they may not be safe for people with low blood pressure.

Harm to people with digestive conditions

People with digestive conditions like Crohn's disease or ulcerative colitis should avoid or limit their intake of pumpkin seeds.

Interaction with medications

Pumpkin seed oil may interact with certain medications, such as antihypertensives. Pregnant or lactating people should also avoid taking pumpkin seed oil in amounts higher than those found in food.

To help avoid side effects, you can practice portion control and eat no more than a serving size (about ¼ cup) at a time.

So take care when taking any unregulated product. My comments are not about Big Pharma so please, if you want to go there, it will fall on my deaf ears (seriously, I'm deaf😜

Professorgary profile image
Professorgary in reply toswwags

You sir have established the importance of discussing any supplements with your mo and pc doctor before taking them.

JohnInTheMiddle profile image
JohnInTheMiddle in reply toswwags

Turmeric was mentioned. Apparently solving the turmeric absorbability problem is extremely difficult. Then there's the problem that apparently the vast majority of turmeric available in North America any form is contaminated with lead and likely other heavy metals too.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toJohnInTheMiddle

Interesting. I just buy well known brand at big box store.

swwags profile image
swwags in reply toTuffNuttoCrack

consider instead, taking your brand to a lab. Why would you think big box stores do their due diligence? They don't test supplements.

TuffNuttoCrack profile image
TuffNuttoCrack in reply toswwags

I got gadolinium poisoning from an MRI contrast agent and a failed kidney from the tumors, the second highest reported concentration on the planet. I “ran” to the lab to get results ASAP as that is life shortening with extreme degradation of your organs. I can very much understand your concerns. A quick search of the Inter “Not” this morning shows a popular internet retailer selling a pill supposed loaded with the oil. My personal take on pill supplements is it’s an unregulated industry and you don’t know what you are getting so as a rule I stay away from them. I take magnesium and a half dose of Turmeric. The seeds were never intended to be a supplement for me at least. It’s a snack food unless one goes nuts doubling and quintupling a recommended serving, if not the reasoning follows that walnuts. Macadamia nuts, pistachios are supplements too. The seeds I get are stamped Non GMO project verified and USDA organic.

docbulldog profile image
docbulldog

Wow, quite the discussion on pumpkin seeds. Since I have exhausted all possible treatments and am now just doing my 3 month shots, I may have to give these a try. Maybe it will bring down my very high PSA..800+

Thanks for the great reads on the topic.

MrG68 profile image
MrG68 in reply todocbulldog

Maybe you could try drinking deuterium depleted water, since you've exhausted all treatments.Typically you could start at ~80ppm. Thats a mix of half a liter tap water with half a liter of 25 ppm DDW.

Nothing to lose... except a bit of money because its not cheap.

TuffNuttoCrack profile image
TuffNuttoCrack in reply todocbulldog

Sorry to hear about your treatment exhaustion, nothing is off the table at this point. My former PCP swears by Ivermectin. I know he personally took it during COVID. Hang in there man, may the Lord identify something that works for you,

carbide profile image
carbide

Some times I feel like a nut;in autumn, I feel like pumpkin seeds.

😁🤔🍁🍂

TuffNuttoCrack profile image
TuffNuttoCrack in reply tocarbide

Organic sprouted ones with only two ingredients …sea salt, The supplier of my stash is labeled at the top of the bag in the picture and has a simple website. But there are bound to be other suppliers. When lunch is cooking and I am hungry I hit the seeds to last a few minutes.

Now that I started the discussion, the big box store is offering em at 12 bucks a bag. Boo! They were $10 yesterday as I walked by the end cap. Inflation!

Stevecavill profile image
Stevecavill

No

TuffNuttoCrack profile image
TuffNuttoCrack

Expensive!

j-o-h-n profile image
j-o-h-n

Fuck the seeds, I'm eating the pie.............

Good Luck, Good Health and Good Humor.

j-o-h-n

TuffNuttoCrack profile image
TuffNuttoCrack in reply toj-o-h-n

You not trying to get the last word in, right John? I was missing your humor so I thought he must be napping.

j-o-h-n profile image
j-o-h-n

Me, getting the last word in..... NEVER,,,

Good Luck, Good Health and Good Humor.

j-o-h-n

TuffNuttoCrack profile image
TuffNuttoCrack

ha, ha! I never seen you filibuster!

85745 profile image
85745

Great to hear you are pro active in your own health, early on I ate a lot of pumpkin seeds maybe I should revisit eating them. What do you thinks about pumpkin seed oil ? My thoughts are always if it can't hurt you and may help , then why not.

TuffNuttoCrack profile image
TuffNuttoCrack in reply to85745

85745 I am sorry I can’t advise you on that. The second article in NIH seems to infer anything pumpkin might hold promise. J-o-h-n is jokingly going for the pie. We can never know as humans if pumpkin seeds make a difference due to the millions of variables involved and the differences in our bodies. But if it works in the lab under perfect conditions, my thoughts would be hey it might help. WHAT IS THERE TO LOSE? But always eat anything in moderation. As I said, have been eating the seeds for a long time without any foreknowledge of any medicinal purposes.

I believe it’s time to give credit to my Lord for his mercy and grace. With my rare, extremely aggressive cancer and only one chemo, I am on his time table rather than the oncologist’s timetable. My oncologist said two years ago to my wife and me based on the similarities with other patients having poorly differentiated cells, I might get a year. Thank you Lord for saving me and making a difference in my life and helping me to use my disease to encourage others! All the best to you 85745.

85745 profile image
85745 in reply toTuffNuttoCrack

Thank you Lord for saving me and making a difference in my life and helping me to use my disease to encourage others! Amen. God Bless

TuffNuttoCrack profile image
TuffNuttoCrack in reply to85745

Bless you brother. I’ll begin praying for you.

85745 profile image
85745 in reply toTuffNuttoCrack

Same here

Kittenlover50 profile image
Kittenlover50

no

TuffNuttoCrack profile image
TuffNuttoCrack in reply toKittenlover50

In the lab yes.

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