Hi warriors - my husband and 3.5 months post taxotere chemo. Now on lupron and Nubeqa. He is having pretty severe pain in his hands and feet. We have discussed this with oncologist and he wants us to work with GP until we can see other specialists (rheumatologist and Neurologist). We went down the rabbit hole of neuropathy and tried gabapanten and lyrica, OTC meds. None work. The only thing that touches his pain is hydrocodone. His Onc doctor feels it’s beyond neuropathy and is reticent to diagnose neuropathy because he might not be able to be part of trials.
I’m starting to think it may be his Nubeqa or chemo inflammation, in addition to neuropathy. His symptoms are: Pain in hands is pins and needles, tingling, pain in tips and joints. He has weakness in hands and his skin appears to be tight
His feet feel numb, toes ache and electrical shooting pain. When he walks it feels like he is stepping on tacks or sharp stones. Balance issues. Also his toe nails are trashed and not chemo related. Like blood spots underneath.
Cold sensitively and can’t feel hot and cold in extremities.
Has anyone else had chemo kick off autoimmune disease or have side effects from Nubeqa. The package says extremity pain is a side effect. Thoughts would be appreciated.
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"... my husband and 3.5 months post taxotere chemo. Now on lupron and Nubeqa. He is having pretty severe pain in his hands and feet...."
Likely from the chemo.
"Patients receiving.. docetaxel [Taxotere] experienced similar symptoms of CIPN [chemotherapy-induced peripheral neuropathy] and similar neuropathic interference with activities. Muscle or joint aches were the most prevalent symptoms and numbness in the feet was the most frequent or constant symptom... Painful symptoms including neuropathic pain, and muscle/joint aches were reported by patients to be more severe and distressing, while painless symptoms including numbness and tingling and loss of balance occurred with greater frequency." ncbi.nlm.nih.gov/pmc/articl...
Sounds like neuropathy, there are products that used vibration to stimulate the nerves in feet and hands. There are also electrical stimulators, I can't remember what it is called. They actually work good. Those work on ankles, knees, elbows, and wrists... PLUS low back.
I experienced mild neuropathy in my hands and more so in my feet. I wore ice packs on both my hands and feet during chemo. I believe it help but I'm still having issues with my feet. Luckily they're very tolerable. My left foot feels cold all of the time but is warm to the touch.
Also, had to have an eye procedure done as the Taxotere clogged my tear ducks causing dry eyes. Wishing you the best of luck.
My husband passed away in 10/22. Remained on this site is to keep abreast ongoing new development of therapy for prostate cancer for our grandsons.
Your husband gets the normal side effects from the taxestere. You may consider to use cold pack on his feet and hands during the chemo to minimize the side effects of his joint pain.
After numerous chemo treatments, my Claude had no feeling of his toes and had to hold onto the handrails to walk up and downstairs.
You have my sincerest condolences about the passing of your dear husband Claude in 2022. I know he's in your everyday thoughts and in your concerns regarding your/his grandsons. God Bless you all.
I'm 2 months past end of same chemo therapy! Numbness and tingling in feet started after second chemo infusion and remains an annoying problem. Two weeks ago, oncologist recommended vitamin B6, so far no improvement.
Yeah, it seems like the vitamins are where they start. He is taking lyrica and it’s not helping. We are going to see his GP this week. I actually just read cymbalta helps some. We just got a good PET CT result so he’s trying not to complain but it’s so bad it disrupts his sleep and day. I’m a fixer and hate to see him suffer. I hope you find relief. Do you want me to keep in touch if we find something?
A very "off the wall" response--so please take it that way. I have no clue about his meds.
However, ALA (alpha-lipoic acid) is used world-wide (but not in America) for diabetic neuropathy, if I remember up to 1600 mg. It's quite innocuous and dirt cheap, I take it because it hinders Ca's ability to create angiogenesis and I'm not on ART yet and hoping to suppress any micromets from adhering and creating a blood supply via angiogenesis.
If it works for peripheral neuropathy for diabetics, it might help. Naturally ask your doc.
"Because alpha-lipoic acid is an unproven treatment, there is no established dose. However, studies have used between 600-1,800 milligrams daily for diabetes and neuropathy; one review concluded that the evidence is convincing for the use of 600 milligrams daily for three weeks on symptoms of diabetic neuropathy.Mar 4, 2023"
I've had Feet/Foot neuropathy for many years (no chemo and prior to Nubeqa) and have been fighting it with Gabapentin with some success as in hitting a long ball single. I have all the symptoms mentioned here on H.U. from time to time and have learned to live with them....Barefoot feet feel like I'm wearing shoes or slippers, burning, pain and etc. So my point is that I can tell for sure it's not the Nubeqa. I am also on quarterly Lupron for many years and the Nubeqa replaced my daily Casodex (which I was also on for many years) in April 2023.
I really hate Pca...... almost as much as I hate my ex-wife...
After starting treatment with Docetaxel, Nubeqa, Lupron two years ago. I experienced pain in both hands and feet. My toes nails discolored and the outer edges of my little toes were the most painful. I met with a hand surgeon and was given a steroid shot on both hands. . Pain on hands did not subside from steroid shots. My oncologist then took me off Nubeqa for seven days. This short break from Nubeqa resolved the issue with the pain in my hands. The pain and discoloration in my feet and toes resolved itself after two years. The pain in my feet was due to neuropathy caused by the Docetaxel. The break from Nubeqa did NOT impact my PSA. My PSA has been undetectable for two years. The only pain meds I have taken when needed were OTC Ibuprofen and Tylenol. Hope this helps. Best wishes.
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