My PSA increased after 6 weeks to 0.04 but my T dropped to 8.87 not sure how to think of this.
I had no expectation, so it is what it is.
Plan is my MO will give me a PSMA scan if a I get to 2.0 PSA.
These numbers are so small that I know that they are meaningless at this point but I would still like to see the trends going in opposite directions ;-((
History
3/12/24 <0.01 Stopped all meds (Lupron, Abiraterone and Prednisone)30 months
4/15/24 <0.01
5/15/24 <0.01
6/27/24 0.03
8/20/24 0.04
Testosterone had been consistently <7 since 11/5/21... until 6/27/24
6/27/24 13.13
8/20/24 8.87
I stopped ADT in March of '24, ( last shot was in De. '23) will see if Radiation and ADT have put me into remission or better yet have "Cured" me.
MO and RO define cure as no rise in PSA for 5 years (March of '29).
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My numbers stayed small after getting off of ADT and about a year later my PSA jumped rom about 0.75 to 2.0. Pylarify PSMA scan show two small lymph nodes, one near aorta and the other in my pelvic area. Pelvic node measured 0.60 centimeters with scan. Radiated the chest node and removed the pelvic node. Also took out 7 surrounding node ( no edema BTW) and they were clean. Just tested my PSA and it was 0.07 and T was 63. I have a call with the surgeon's PA to discuss. Not much to discuss; just going to eat healthy, get sleep, with train with trainer and get cardio on the treadmill. Literally working out 6 days a week.
UTSW said that they want to take this aggressive move because I am a young 72 YO!
I agree, not enough data so no need to be concerned yet. It could plateau at some point above where your at as well and stay there. Here's to your being cured 🥂
My guess would be yes but no desire to do so right now. Mental/emotional side effects were tough on me, almost destroyed my significant relationship. Fortunately all is good now.
I've been on lupron now for three and a half years now. My psa has been undetectable since last November. I was going to stop the lupron and decided to stay the course for now. Outside of hot flashes every now and then it's been doable. Good luck to you.
Read your bio. That has to have been the most complete one I have ever see or read. Great job! Now if I was a doctor I probably would be able to you a more scientific analysis but here is what I know after reading your bio and knowing my case.
We are roughly the same age (79) and we do have similar exercise regimes and you have a better diet.
I was Gleason 7 (4+3) and had pelvic and prostrate radiated and 6 months of Lupron about 15 months ago. My T is back to my normal which is around 700. My PSA was <.01 while on the first 4 months after radiation and on Lupron.
After that it remained <.01 for about 3 months and then jumped to .04 and has stayed at .05 for the last 6 months. My MO and RO were not concern at all. They gave me two points that may help you. As T comes back PSA will rise and they really see a well defined nadir after radiation of .05. They were so positive that the RO said see you in a year and the MO said your choice 6 months or a year. I took the 6 month option.
I had to convince myself so last month I paid for a PSA test. Guess what! Drum role, please. PSA was .05.
So I relaxed and hummed a old Doris Day song - What ever will be Will be. Will be.
It does thanks. and I like you song choice I am a bit more concerned as my Gleason score was 9 and I have come to understand that it may return because it is/was more aggressive. I am envious of 700 T , at age 66 mine was only 490 prior to PCA.
I have been thinking about this comment and here are my thoughts. If the cancer is contained within the prostrate there is really not much difference between a 9 and a 7 providing the radiation is done correctly and it kills the cancer. You should be good to go.
Just need to monitor your PSA to determine your nadir and watch for any biological recurrence.
Scott keep in mind that T changes based on time of day, exercise, etc so it is not a very definitive test. Over time the trend is reflective more so then the specific number which can bounce around.
You're still castrate...so why the rise in PSA? I remember when I started my time off ADT + zytiga after curative intent. It was < 0.04 for 6 months and my T was returning to pre treatment levels. At 6 months my PSA jumped to 0.3.
Had Pylarify scan around .8 given the PSA trajectory and the scan came back negative.
Returned to mono ADT treatment at basically 12 months mark.
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Different Outcomes 
PSA dropping, yet testosterone rising on Lupron/Zytiga??
Stymied and worried
Post RP PSA rising? 
