trojan horse to kill cancer, an agnostic system

[Maxone73]

ok Newsweek is not the best scientific source but the system is interesting:

newsweek.com/cancer-breakth...

[Ian99]

Thanks for posting this. I did notice this: “recent research has shown that these masses of dying cells may actually promote cancer metastasis, where tumor cells break off and spread through the rest of the body.”

This makes me wonder about dying cells caused by parp inhibitors for those on drugs like Lynparza.

Apart from that it looks promising.

[KocoPr in reply to Ian99]

That’s where senolytics come in.

ncbi.nlm.nih.gov/pmc/articl....

Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies. Consequently, senolytic use has been proposed as a potential adjuvant approach to improve the response to senescence-inducing conventional and targeted cancer therapies. Despite the unequivocal promise of senolytics, issues of universality, selectivity, resistance, and toxicity remain to be further clarified.

[dhccpa in reply to Ian99]

Don't many treatments create dying cells, including chemo and radiation? That's been my understanding, but I defer to others.

[Maxone73 in reply to dhccpa]

it's not the rule, but yes, it can happen even with chemo:

ncbi.nlm.nih.gov/pmc/articl...

I don't know if also with PARP inhibitors, I think (but it's just my opinion) we must consider which kind of death is involved, you know that cancer cells can die following different paths

[Ian99 in reply to dhccpa]

I see what you mean. I thought this was related to cancer cells rebuilding their DNA, which the PARP inhibitor had previously stopped. As you say, I’ll defer to others more knowledgeable.

[Graham49]

Here is Yale Medical School article

m.yale.edu/cq2y