Does lupron/zytiga cause peripheral neuropathy as side effect?

[pj1121]

I have been on Lupron for a year Aberaterone and prednisone for 10 months. Quite suddenly about six or seven weeks ago I developed peripheral neuropathy In my feet and toes. Mild pain, but constant really bad, stinging in my toes and feet. I’ve read that neuropathy can be a side effect of aberaterone but it is not very common. Walking and wearing shoes really aggravates it so I am trying to find the cause and was wondering if anybody had a similar experience and what they have done about it if anything I would consider changing medication it is so aggravating

so much for any response

pj

[JohnInTheMiddle]

May I ask how's your blood sugar?

[pj1121 in reply to JohnInTheMiddle]

Normal range last time tested about six weeks ago

[Derf4223]

Foot swelling/edema?

[pj1121 in reply to Derf4223]

No foot swelling or edema

[Mascouche]

I have had neuropathy in my feet while on Lupro+Zytiga+Prednisone but I can't say for sure if it was a result of the drugs or of radiation since those issues began about 7 months after then end of my radiation treatments.

I said I have had but should probably say still have because it comes back if I stray from eating low carbs or if I stop supplementing with R-Lipoic acid and Benfothiamine. I also take some vasodilation supplements such as L-Arginine and L-Citruline to open up my blood vessels so that my feet no longer torture me in the evening.

That said, do not copy me without speaking to your doctor first because if your blood is already thin, the vasodilation supplements would probably not be a good idea for you.

Best of luck!

[pj1121 in reply to Mascouche]

Thanks. Mine started 6-7 months after radiatiin as well. I had ebrt 28 for 70 g to prostate pelvic nodes and retroperitoneal nodes.

[SViking]

I also have foot neuropathy from ADT. Believe it or not, wearing socks at night relieves the symptoms.

[leo2634]

I tried all of the over the counter remedies nothing really works so Doc prescribed a low dosage of Gabapentin and in a day or so all pain is gone. Never give up Never surrender Leo

[jmarsh]

Are you on a statin drug for cholesterol? I had similar issues and stopped my statin for a while. Neuropathy almost went away. Obviously, you should only try this with your doctor’s blessing. I just finished 2 years of Lupron and Abi. Gonna try my atorvistatin again next week.

[Eieio]

I was on the same treatment and noticed very dry skin on my lower legs and calves. Neuropathy and high glucose are very much connected. Pay close attention to sugar intake or stop completely. That combination of lupron and zytiga pushed my glucose fasting #’s and AIC up to pre diabetic levels. Went on low carb diet for 4 months and returned to normal after the ADT ended. However I’m back on a new regime so stay vigilant . You may inquire about performing or other to lower the glucose levels. I would not wait six weeks for a glucose test.

[pj1121 in reply to Eieio]

I have noticed very dry skin on my lower legs and calves similar to you Does that somehow imply high glucose levels?

Thank you

[Eieio in reply to pj1121]

Pj1121 I don’t have a study that confirms this but I have been in blood diagnostics, life sciences and now developing diabetes wearable infusion pumps. I pay attention, look and listen to the patients. I experience the dry skin then started paying attention to anything that increased glucose levels. So I would imply that glucose levels can cause dry skin and any form of neuropathy, extremities even the eyes . I have not allowed my blood glucose levels to go past the high limit. I stopped carbs started looking at herbal augmentation to keep that from creeping up. Costas postus, it’s a ginger, you use the leaves. There are many signs and symptoms before neuropathy and pre diabetes gets a hold. I would highly recommend looking at anything that lowers your glucose sensitivity. It’s a highly published. Subject matter for diabetics, but not as much focus as us on these drugs that actually do the same thing being diabetic. One last rant I had a post on reducing methionine and 2 DH glucose. PC cells need glucose about 4x to replicate , starving out glucose with glicine, spermadine, resveratrol even metformin for castrate resistance. Always consult your Healthcare provider. The way I see it these are SE of the medication and an augmented path aid the elimination of PC cell replication

[j-o-h-n]

Seems like I've been on Lupron forever. I have peripheral neuropathy and have been on Gabapentin forever. After dealing with my ex-wife I've learned to tolerate the neuropathy symptoms.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Eieio in reply to j-o-h-n]

J-o-h-n After dealing with my ex-wife I've learned to tolerate the neuropathy symptoms.

That’s well said

[j-o-h-n in reply to Eieio]

Let's form a club.... I nominate you as president, and I'll be the comptroller in charge of cash donations...... We can sell our ex-wives to Hamas.... Deal?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Eieio in reply to j-o-h-n]

I’m reading this in tears !!! Hamas was added special sauce

[j-o-h-n in reply to Eieio]

Youbetcha, secret recipe house sauce...... I figured might as well take care of two birds with one stone...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Iscetic7 in reply to j-o-h-n]

Haha. Yes, so funny jesting at people resisting occupation and genocide.

[j-o-h-n in reply to Iscetic7]

Greetings Iscetic7,

Pardon me... I forgot to introduce you. "Ladies and Gentlemen, we have a golden thrush in the audience". Would you be kind enough to" sing in" your bio? All information* is voluntary but it helps you and helps us too. Thank you!!!

*E.g. age? location? Pca stats? meds? doctor's name(s)? where being treated? past and current PSA numbers? Gleason score? various treatment(s) and etc.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Iscetic7 in reply to j-o-h-n]

Yes. So helpful.

[Don_1213]

Peripheral neuropathy can have quite a few causes.. diabetes is one, the nerves are attacked in the legs and feet eventually dying off but causing lots of pain. PAD - peripheral artery disease - poor circulation has the same effect as diabetes - nerves don't get enough blood and start dying off causing pain. Stenosis (disk compression, splitting, displacement etc) and osteophytes (spinal bone spurs) on the 2L-3L and 3L-4L can pinch the nerves going to the legs - causing numbness up higher in the thighs, and numbness and pain in the lower extremities.

I have all of those. I've done the rounds of specialists, and there isn't a lot they can offer. Back surgery (laminectomy) to reduce the osteophytes - 50/50 might help, might make it worse. Back surgery - fusing vertebrae to keep them from pinching the nerves and disks - major surgery, 50/50 - might help, might cripple you. These were the odds I got from the head of back surgery at a major NYC medical school back surgery department. He wasn't very enthusiastic about doing either, he said he'd "rather not.." If I was a decade younger I think he might have been more interested.

So - it's gabapentin - which only relieves stationary off-my-feet pain. If I try to walk any distance - it becomes intensely painful, as does even standing around. After a while you learn to spot other guys with the same issues - look for the guy in the supermarket using the shopping cart as support so he can walk the isles. That might be me - might be you.

This is an instance where the over-reaction to opioids where no MD wants' to be seen handing out opioid prescriptions, has done a disservice to people who are really in pain.

I can't say 18 months of Lupron caused this - but it sure didn't help. At least some of it is heredity, my father had PCA and was on life-long Lupron from about 75 until he passed at 87 - had the same issues, and finally couldn't walk at all.

Part of this may be partly caused by the cardio issues ADT can cause - if you're on or going on ADT, find a cardiologist and do a workup.

[jfoesq]

I have been on Lupron for most of my 12 yrs since Dx and Abiraterone for almost as long. Just a few weeks ago, the little toe in my right foot can send me very infrequent sharp pain when I bend the toe. I don’t know if it is neuropathy and it hasn’t been a big problem for me. Whatever the condition is, if it stays this way, I will be happy. I just don’t want it to worsen.