Peripheral neuropathy and Zytiga - Advanced Prostate...

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Peripheral neuropathy and Zytiga

Frigataflyer profile image
20 Replies

After ten months Zytiga has failed me and my PSA doubling time is about two months. I am switching to Xtandi.

For At least four months I have had paraesthesias on the balls of my feet. The paraesthesias are most notable when I get out of bed and touch the tile floor at night. They feel like there is a thick layer of dead skin between my receptors or sometimes the experience is similar to that which occurs when local anaestesia is wearing off.

They have been along way down on my list of medical concerns, but now the paraesthesia is changing to include a burning sensation. If anyone has had experience with this problem, I would like to know about the progression because, it feels to me as if my finger tips are showing signs of something similar.

My last glucose was 80 (can’t) remember the units but I am pretty sure I am not diabetic.

Thank you in advance.

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Frigataflyer
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20 Replies
Tall_Allen profile image
Tall_Allen

Have you tried Neurontin or Lyrica?

Frigataflyer profile image
Frigataflyer in reply toTall_Allen

No but I am Googling them as we speak. Thank you

in reply toTall_Allen

My buddy tried lyrica and he couldn’t drive anymore .

Hairclubpresident profile image
Hairclubpresident in reply to

He could try gabapentin, it is similar to Lyrica, but sometimes one will cause dizziness and/or extreme sleepiness, but the other will not.

tango65 profile image
tango65

Zytiga has not been associated with peripheral neuropathy.

accessdata.fda.gov/drugsatf...

If you are not diabetic you need to consult with a neurologist to try to determine what is causing the neuropathy.

Hairclubpresident profile image
Hairclubpresident in reply totango65

No, there is only one confirmed report in a Zytiga patient, which is clearly in the spectrum of co-incidental (in the truest form of two incidents, which are not necessarily related, occuring at the same time). However, Lupron has definitely been shown to lead to neuropathy, it is fairly likely that someone receiving Zytiga has already had Lupron.

Oh yah! I’ve got this too. Getting very bad now after over six years with no t. My nat dr just advised me to start taking glucosamine chondroitin and msm together . I used these as a weightlifter at times before pc . I hope this does help. Massage helps. Hot and cold with Epsom salts helps hands and feet . Now my arms go numb at night ending in great pain in my thumb joints. All new in the last six months. I asked my gp he prescribed gabatin and Celebrex but after reading the side effects I tossed them . I’m Sorry that you suffer this as I do . We need to keep our joint moving with no impact .Addios ! 💪

cashlessclay profile image
cashlessclay in reply to

Dr. Myers would advise against the use of chondroitin-sulfate which is common in "joint" supplements.

malecare.org/treatments/hor...

CAMPSOUPS profile image
CAMPSOUPS in reply tocashlessclay

Hmmmmm. Thanks for that. I sometimes recall the gluco/chondroitin tablets prescribed to our poor old Newfoundland back in the day when she was alive and was aware it is available for humans and thought about taking it.Although the evidence might not be absolute against chondroitin it appears if I want to experiment I better not take the combo and take just the glucosamine alone. Just to be on the safe side.

By the way our veterinarian told us the gluco/chondroitin tabs from veterinary pharmacy were controlled production and that those available at wal-mart etc. for human use were liable to be uncontrolled in there quality.

Frigataflyer profile image
Frigataflyer in reply toCAMPSOUPS

Gracias

Frigataflyer profile image
Frigataflyer in reply to

Thank you for the tips

TheGurkin profile image
TheGurkin

I have experienced this for many years I have over come this so that I get a nights sleep by wearing a pair of Daps/Plimsolls in bed Yes in bed it restricts movement of my toes and I’m able to sleep .

Frigataflyer profile image
Frigataflyer in reply toTheGurkin

It is not interfering with my QOL now but I will keep Daps/Plimsolls in mind thanks

podsart profile image
podsart

I am dealing with “burning sensation “ bottom of feet at times. As in my case, it can be caused by spinal stenosis , especially in the lumbar region. In my case L3/L4 are the main culprits. The sensation apparently is one of feelings caused when spinal nerve is impinged, as well as possibly numbness and tingling.

Frigataflyer profile image
Frigataflyer in reply topodsart

Do you have any other symptoms of spinal compression? I have had pain associated with lumbar discs but for yesrs now i have had no back problems.

Fightinghard profile image
Fightinghard

Same problem. Feet numb and legs like rubber. I think its side effects from the lupron or low t. Or both

CAMPSOUPS profile image
CAMPSOUPS in reply toFightinghard

For over a year and chemo was the main culprit it feels like i have pushed my feet into shoes full of sand. There is a disconnect between the bottom of my feet and toes and the ground on which I stand/walk.Sometimes I drive in my socks. I like the more direct link between my feet and the pedals but even in my socks there is a void in sensations.

Frigataflyer profile image
Frigataflyer in reply toCAMPSOUPS

I prefer to walk barefoot on tile floors

CAMPSOUPS profile image
CAMPSOUPS in reply toFrigataflyer

Me too. Or barefoot in sand which I rarely have the opportunity to do.

Frigataflyer profile image
Frigataflyer in reply toFightinghard

Low T Lupron, Zytiga, Bicalutamida is all I have to blame it on.

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