"Supraphysiological testosterone induces ferroptosis and activates immune pathways through nucleophagy in prostate cancer."
"Chemokines and cytokines secreted by the tumor cells in response to SupraT resulted in increased migration of cytotoxic immune cells to tumor beds in xenograft models and patient tumors. Collectively, these findings indicate that SupraT may inhibit a subset of PCa by activating nucleic acid sensors and downstream immune signaling."
One of the authors is Sam Denmeade.
"SupraT may inhibit a subset of PCa..."
As always, the question is: how to figure out in advance of T-therapy exactly who is in that subset and who isn't?
Maybe I'm wrong, but I took it to mean a subset of normal PC as found in most of us?
What I am trying to say is that I understood the meaning of "subset" to be that in typical PCa there are subsets in each person, not that some people have one kind of subset and some have another kind.
That's what I think also. But who has how much of which?
From FB: View them as separate tribes, if you will. Nurture one while decimating the other. Then switch gears and decimate the first tribe while nurturing the second.
But this falls apart if we have low androgen sensitive, high androgen sensitive, and androgen ambigous tribes! Then the challenge would be to figure out how to control/attack the third tribe. BAT is for two tribes.
That may be the case, that in typical PCa there are subsets in each person, but what I am saying is that their must be differences between men based on the different responses of different men's PC to supra-T... so how to know beforehand which men will respond which way?
I agree that it would be very good information.Until we know that answer I would propose that during earlier stages of PCa it would be best to find out if you're in the lucky group.
My PSA was zero when I started SPT. I didn't know if it would stay low or increase but I figured I had lots of headroom so now was the time to find out.
Lucky for me it stayed at zero for a year, and scans were negative, and then my PSA slowly went up to 0.039 and then rapidly climbed to 0.17. I went on ADT with SARMs and in a few weeks it was back to zero. In another month or so I'll go SPT again and then cycle SPT/Nandrolone/ADT-SARMs.
what are SARMS?
Selective Androgen Receptor Modulators. Theory is that they stimulate muscle and bone without much prostate stimulation. They seem to work for me. I can tell that my androgenic stimulation is low (hence libido). But I am getting stronger and more muscular.
Thanks, good luck
I google SARMs and see all kinds of ads, for example paradigmpeptides.com/produc...
I hear others are using Rad-140. Of course I am not!!!
There are many sources of Testosterone Cypionate online.
I'll take a risk with some orals. As long as they are 3rd party lab tested and have happy users. I think that they are probably just as safe or safer than the supplements we don't give a second thought to swallowing (from an impurity standpoint). But I try to go the pharmacy route when possible. I get cyp from a TRT doctor. I know it's good cyp and it's also quite a bit cheaper than getting it online
A friend of a friend of my late cousin uses chemyo.com. I heard that this remote friend (I don't know their name - sorry) bought from 3 sources and did some research and talked to some other unknown individuals before they decided that chemyo seems legit. And I also heard from another source that the oddball person using the SARMs has no testosterone yet put on lots of muscle in a short period of time (I have a terrible memory and can't recall their name).
I always look for that keyword "MAY" -- "...these findings indicate that SupraT MAY inhibit a subset..." ...or may not. Let me know when it reads "SupraT DOES inhibit..." then maybe I'll pay more attention.
Happy to see that the research on SPT in PC is continuing in major institutions.
does anyone have link to pdf of full article?
Way over my pay grade so I think I'll stick to playing with my playdoh...
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/28/2021 7:00 PM DST
That's why I was against the $15 minimum wage
Hourly or weekly?
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/28/2021 9:40 PM DST
Ah yes..... I forgot Santa Claus.....runs the government........... 😀
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/28/2021 10:07 PM DST
Yes Virginia I do believe..too!!
She also was told to believe in the tooth fairy, the Yankees, Mets, Giants and Jets...and the guy who said he would only put it halfway in,,,,,
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/28/2021 10:24 PM DST
Leave the Yanks out of it!!!
They're already out of it.........
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/28/2021 10:40 PM DST
🤣You had to remind me!
No matter who plays...... they're all robots............ what they need is helmet (cap) cameras........more cameras the better.....forget live umps..........
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/28/2021 10:57 PM DST
How about eating a healthy snack that might help fight PCa. Lotus seeds (Nelumbo nucifera) also known as makhana contain Neferine, see below
p53 mutant-type in human prostate cancer cells determines sensitivity to phenethyl isothiocyanate (Watercress) induced growth inhibition
Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate CancerProlactin & Cabergoline.
Is surgery, radiation or Lu-177 therapy appropriate for my case? 
