Results from 4 Genomic labs

[JolleySprings]

3 years ago we received a Foundation ONE Report giving us the report he has CDK12 mutation.

He has been on Lupron, NUBEQA, and Zytiga.

Over time they have failed.

Recently, 4 lymph nodes were removed for thorough testing to make sure C had not mutated into Neuroendocrine. It had not. Actually, the 3 reports are very similar to the one from 3 years ago.

We received reports from:

BostonGene

Exact Sciences

Sage Medic

RESULTS:

TMB(Low)

MSI (Stable)

Tumor Content (34%)

Negative for PTEN & TP53

KEY MARKERS:

AR(ARv7) high level amplifications

CDK12 (D1022fs)

CDK12((S133fs)

Tumor Microenvironment:

Immune-Enriched/non-fibrotic

PDL1- Expression High

Angiogenesis high expression of VEGFRI

MEMORY T-Cell signature High (100)

Cytotoxic T-Cell signature High (96)

The treatment recommendations vary from each report.

Dr. Aggarwal suggests Immunotherapy Clinical trial.

Dr. GHANDI suggests ADT + Docetaxel

We are also looking into the clinical trial OR-503 m AB (Cemiplimab/Libtayo)

There are so many variables for eligibility in Clinical Trials. He is excluded from many bc of no chemo as of yet. Plus, many require bone metastasis.

Thank you for any thoughts!

[Tall_Allen]

Have you investigated clinical trials that target CDK12?

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

classic.clinicaltrials.gov/...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

[spencoid2 in reply to Tall_Allen]

only one of these mentions anything about cdk 12 why do the other trials "target CDK12"

[MoonRocket in reply to spencoid2]

I'm going out on a limb but I think it's to due to the inclusion of abemaciclib.

[spencoid2 in reply to MoonRocket]

but abemaciclib is a cdk4 and 6 inhibitor nothing is mentioned about cdk 12

what type of cancer is verzenio (abemaciclib) used for

Verzenio is a CDK4 & 6 inhibitor used to treat HR+, HER2–, node-positive, early breast cancer with a high risk of coming back as determined by your doctor. Verzenio works to block specific proteins called CDK4 & CDK6.

[Teacherdude72]

I was initially diagnosed in the fall of 2015, G9, aggressive, received radiation then HDR Brachy. Lipton . Returned to PSA of 4 in my ate 2019.Lipton again but in mid 2020 it too filed, osa again 4.

Started Nubeqa with Lupron. PSA hit less than 0.012 for three years. Did have ogolionetastic treated with radiation.

Now on holiday, 6th month