Glutamine-blocking drug slows tumor growth and strengthens anti-tumor response

[Panas]

Glutamine is an amino acid. Cells are dependent on glutamine in many different ways. Cancer cells in particular are highly dependent on glutamine. Without glutamine, cells would stop growing and eventually die.

Cancer cells’ addiction to glutamine has long tempted cancer biologists as a potential Achilles’ heel for treating the disease. Perhaps by cutting off the supply of this amino acid, one could starve cancer cells to death. Inconveniently, normal cells need glutamine too. Therefore, drugs that affect glutamine levels in the entire body are too toxic to use as cancer therapy.

Now researchers in Johns Hopkins found a compound which blocks glutamine metabolism and can slow tumor growth. Moreover, the compound, a “prodrug” version of the glutamine antagonist DON, selectively targeted tumor cells because they are the “hungriest” for glutamine.

Research showed spectacular results in mice. We all know of course, that most drugs that work in mice don't work in humans, so we should wait for trials in humans to see if such a compound may form the basis of an new effective cancer treatment.

eurekalert.org/pub_releases...

[math33]

Hope it's fast tracked.

Larry E

[TFBUNDY]

Thanks Panas. Good one. DON... THE SCIENCE IS COMING...!

[MINE2 in reply to TFBUNDY]

Please, don't mention stuff that remains in limbo. Thanks

[TFBUNDY in reply to MINE2]

That's a message to our friend DON PESCADO. Dohhhh.. . Keep up! Cheers

[Nirman]

I ve said this earlier but nobody belived me cancer thrives two ways..one is glucose and other is glutamine so we need to block both so first put yourself on keto(don't use dairy and red meat) to take care of glucose and for glutamine it's "DON" as glutamine is almost in evry food so DON inhibits glutamine to get absorbed in our cells, there are other natural ways to inhibit glutamine too like green tea, bell peppers and ashwagandha (Indian ayrveda herb), watch these videos youtube.com/playlist?list=P... and search dr Thomas Seyfried for more details read his book cancer as metabolic disease prevention by methabolic therapy...what he clams is ..if you can't cure but definitely stop and slow down the progress for many many years naturally

[MINE2 in reply to Nirman]

... favor, please. Don't assume everyone knows what is meant with initials (DON?) spend the extra second it takes to spell-out your references. Thank you, sir.

[Nirman in reply to MINE2]

Very sorry I apologise.....well let me throw some light ........6-Diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist, which was isolated originally from Streptomyces in a sample of Peruvian soil. It is a non-standard amino acid. The diazo compound was characterized in 1956 by Henry W Dion et al.,[2] who suggested a possible use in cancer therapy. This antitumoral efficacy was confirmed in different animal models.[3] DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. The last clinical results were published in 2008, though not as DON monotherapy but in combination with a recombinant glutaminase.[4] In 2019, DON was shown to kill tumor cells while reversing disease symptoms and improve overall survival in late-stage experimental glioblastoma in mice, when combined with calorie-restricted ketogenic diet

[Nirman]

youtu.be/o1i4EMq3dcQ(Not working as expected?) go through this please