I have to have pathology on tissue done for second opinion as I’m not sure if they did a complete staining histology
It Thankfully came back as pca Adenocarcinoma
Still believe it seeded the liver lesions / mets and lung nodules from growing tumor on prostate bed, that I never radiated…see bio
Anyone know anything about the best parp inhibitors that I may successfully respond too or ATK inhibitors?
Information:
Taken together, these data suggest that ATM loss is a potential biomarker for ATR inhibitor sensitivity in prostate cancer and that ATR inhibition may be a more promising therapeutic strategy than PARP inhibition for the subset of prostate cancer patients with tumor ATM loss.”
Unfounded belief about spread. You don't seem to understand that cancer growing into prostate bed are not mostly metastases, and that the cancer must be metastatic to spread. I don't see how such fantasies help you, but believe whatever gets you through the day.
You are looking at outmoded data. The ATR inhibitor clinical trial was terminated early because of no benefit.
During chemo is a good time to use it. It amps up the immune response, which would be otherwise depleted by chemo. Also, chemo makes more cancer antigens available to dendritic cells, so Provenge may work better. They may work synergistically.
A. Liver, lesion, biopsy: Small focus of metastatic prostatic adenocarcinoma; see note.
Note: The biopsy shows hepatic parenchyma with a small focus of adenocarcinoma that stains positive with a NKX3.1 immunostain, supporting the above diagnosis.
5/6/2024 GROSS DESCRIPTION: A. Received fresh, the specimen is labeled "liver biopsy mass X6" and consists of seven cores of tan-white tissue measuring from 1.0 x 0.1 x 0.1 to 1.3 x 0.1 x 0.1 cm. Four is/are submitted for ancillary studies. The remaining tissue is entirely submitted for routine histology. Summary of sections: A1 to A3. (SHS/CBS)
That is just an anecdote. It would be wrong to conclude that "parp inhibitors are successful against ATM mutation." While the experimental drug (AZD5305) might or might not be, none of the FDA-approved PARP inhibitors are effective against ATM mutations.
if I remember correctly with ATM your response to PARPi is not as good as it is with BRCA but better than if you have no mutation. Actually some secondary analysis reported that also some non atm /BRCA mutants can benefit. ATR seem to work better: keep an eye on this trial aacrjournals.org/cancerdisc... from Bayer
But there are other being tested even if I think that many are tested for ATM mutation but in breast cancer and in combo with PARPi
May I suggest you ask your MO why Keytruda would be effective for you. My assumption is your TMB. If this is above 10, then doctors can prescribe for PCA. If not, then I would ask what the treatment is supposed to gain for you. No one on this site has a crystal ball or personal insight into your specific conditions, only your MOs do.
I agree with TA about considering Provenge. Another nice thing about it is the low/ almost zero SEs. I had it alone five years ago and it seemed to help significantly. Getting insurance to pay for it was another matter. Good luck whatever you decide!
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Published 2019 May 8: A Novel Patient Case Report to Show the Successful Termination of Untreatable Androgen-independent Prostate Cancer: 
Luteolin Inhibits Human Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2-Mediated Angiogenesis
Anti-Depressants and Cancer Survival
