Anyone on Balversa trial x prostate cancer?

[Michelle56pr]

My b.f. has been through chemo, radiation and all types of oral meds. Currently his tumors have multiplied and we are considering a Balversa clinical trial vs immunotherapy.

Does anyone tried this med before? Thanks , would appreciate any feedback.

[tango65]

Does the cancer have abnormal fibroblast growth factor receptor (FGFR) gene?

balversa.com/about-balversa...

janssenlabels.com/package-i...

pubmed.ncbi.nlm.nih.gov/333...

[Michelle56pr in reply to tango65]

Thanks for the information, will review , much appreciated.

[tango65 in reply to Michelle56pr]

Best of luck!! Discuss in detail possible side effects and benefits of this drug. Do they know the genome of the cancer? Did he have LU 177 PSMA treatment or treatment with platinum compunds (cisplatin) or similar?

[Michelle56pr in reply to tango65]

We are trying to buy some time. We go to Md Anderson, and it appears that the Lu 177 might be an option in the summer. On the other hand his tumors are out of control. He started spending his days in bed , just hoping to make it to the next step. Thanks for your concern.

[tango65 in reply to Michelle56pr]

I wish you the best of luck.

[Tall_Allen]

On the one hand, Jeremie Calais is reporting limited success in detecting prostate cancer with fibroblast activating protein inhibitors (FAPi). On the other hand, fibroblast growth factors seem to be highly expressed in prostate cancer stroma, so inhibitors (like Balvarsa) may inhibit tumor growth.

There is a randomized clinical trial that combines a different fibroblast growth factor inhibitor (MGM831) with an immunotherapy (Keytruda), So (depending on randomization), it may be possible to get both:

clinicaltrials.gov/ct2/show...

[Michelle56pr in reply to Tall_Allen]

Thanks for your quick response. We are at a crossroads, as many of the members of this group. Will keep you posted of the final decision.

[Michelle56pr]

Thanks, he will be tested this week.