I’ll likely be starting Pluvicto treatments soon, and am looking for advice/suggestions to help minimize damage to healthy organs/tissues which normally have PSMA avidity.
Primary the salivary glands, but kidneys and liver too. Drinking LOTS of water prior to and following infusion is a must, of course; but I’m also wondering about things like sucking on sour candies to ramp up the expression of saliva, or maybe adding some herbal teas known to help flush toxins from the liver.
Anyone have experience or knowledge of anything along those lines? Thanks!
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Shams_Vjean
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I don't understand how you can say that xerostomia is temporary if you read the article you linked. They are referring mainly Ac-225-PSMA-617 but it also occurs with Pluvicto LU 177. Lasting damage is not very common but it does occur.
"Lasting damage may result from radioablation of the saliva-producing cells and the nerves that innervate them, and their replacement with and obstruction of the ducts with mucus and scar tissue. Loss of saliva can make chewing and swallowing almost impossible, leading to choking and vomiting. Digestion is impaired, and the ability to taste food may be lost. Saliva has antimicrobial properties, so its loss can lead to tooth decay, gum disease, and oral thrush. Speaking can become difficult. It can feel like burning, and interfere with sleep. Humans normally produce about a liter of saliva each day."
Hopefully, you don’t have a history of ONJ (Osteonecrosis of the Jaw)which can be produced by taking bone strengthening medication like Zometa. I did get ONJ from taking Zometa so taking Pluvicto for advanced prostate cancer is not a great option…….salivary gland function can likely be lost permanently. Therefore, the ONJ healing CAN stop and really become irreversible.
As you mentioned plenty of water is good. Eating a plant based diet helps keep things moving, also, I drink several cups of ginger-tumeric tea every day.
I once met a guy who worked with cancer patients. He built a device with a small tube going to a wearable reservoir under a shirt containing water + whatever. The liquid was continuously pumped to the corner of the patient's mouth.
This was a decade or so ago. I have no idea whether it was commerialized, and I don't remember his name or where he lived.
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