Evidence that lidocaine (a local anaesthetic) has anti cancer properties

[Graham49]

Lidocaine Inhibits Rat Prostate Cancer Cell Invasiveness and Voltage-Gated Sodium Channel Expression in Plasma Membrane

Brief Report

Published: 02 January 2024

The Journal of Membrane Biology

Nahit Rizaner, Scott P. Fraser, Ilknur Bugan Gul, Esma Purut, Mustafa B. A. Djamgoz & Seyhan Altun

Abstract

There is increasing evidence, mostly from breast cancer, that use of local anaesthetics during surgery can inhibit disease recurrence by suppressing the motility of the cancer cells dependent on inherent voltage-gated sodium channels (VGSCs). Here, the possibility that lidocaine could affect cellular behaviours associated with metastasis was tested using the Dunning cell model of rat prostate cancer. Mostly, the strongly metastatic (VGSC-expressing) Mat-LyLu cells were used under both normoxic and hypoxic conditions. The weakly metastatic AT-2 cells served for comparison in some experiments. Lidocaine (1–500 μM) had no effect on cell viability or growth but suppressed Matrigel invasion dose dependently in both normoxia and hypoxia. Used as a control, tetrodotoxin produced similar effects. Exposure to hypoxia increased Nav1.7 mRNA expression but VGSCα protein level in plasma membrane was reduced. Lidocaine under both normoxia and hypoxia had no effect on Nav1.7 mRNA expression. VGSCα protein expression was suppressed by lidocaine under normoxia but no effect was seen in hypoxia. It is concluded that lidocaine can suppress prostate cancer invasiveness without effecting cellular growth or viability. Extended to the clinic, the results would suggest that use of lidocaine, and possibly other local anaesthetics, during surgery can suppress any tendency for post-operative progression of prostate cancer.

SOME OTHER LIDOCAINE CANCER STUDIES

Li R, Xiao C, Liu H, Huang Y, Dilger JP, Lin J (2018) Effects of local anaesthetics on breast cancer cell viability and migration. BMC Cancer 18(1):666. doi.org/10.1186/s12885-018-...

Liu T, Jiang F, Yu LY, Wu YY (2022) Lidocaine represses proliferation and cisplatin resistance in cutaneous squamous cell carcinoma via miR-30c/SIRT1 regulation. Bioengineered 13(3):6359–6370. doi.org/10.1080/21655979.20...

Soto G, Calero F, Naranjo M (2020) Lidocaína em cirurgia oncológica: o papel do bloqueio dos canais de sódio dependentes de voltagem. Revisão narrativa [Lidocaine in oncological surgery: the role of blocking in voltage-gated sodium channels. A narrative review]. Braz J Anesthesiol 70(5):527–533. doi.org/10.1016/j.bjan.2020...

Sun M, Huang S, Gao Y (2021) Lidocaine inhibits the proliferation and metastasis of epithelial ovarian cancer through the Wnt/β-catenin pathway. Transl Cancer Res 10(7):3479–3490. doi.org/10.21037/tcr-21-1047

Xing B, Yang L, Cui Y (2022) Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation. Cancer Biomark 33(3):317–330. doi.org/10.3233/CBM-210249

[KocoPr]

I wonder (i am sure) if it is only temporary until the lidocaine has been metabolized? Which would mean a regular dose and where? Directly on the tumor’s

Extended to the clinic, the results would suggest that use of lidocaine, and possibly other local anaesthetics, during surgery can suppress any tendency for post-operative progression of prostate cancer.

[Graham49 in reply to KocoPr]

More research is needed of course, although I doubt that drug companies would be interested. Lidocaine patches are available.

[KocoPr in reply to Graham49]

The doctors also inject it mixed with cortisone shots. (The huge needle then they move it around injecting more cortisone.) painful but oh so worth it.

maybe the patches can be used on bone Mets as those are near epidermis's

[Still_in_shock in reply to KocoPr]

My knee injections!!!

[KocoPr in reply to Still_in_shock]

Torn acl one knee and torn miniscus on another knee

[Still_in_shock in reply to KocoPr]

ACL, Minuscus, and MCL on one!!

Yeah, my heel was in my ear!!

[KocoPr in reply to Still_in_shock]

No Acl decades ago doing marshal arts got repaired then needed cortison shot 15 years later. The other knee compund tear of meniscus 4 months ago breaking up dogs fighting in the woods ( not my pretty pitty she is to sweet)