Genistein for PCa hormonal control.

nature.com/articles/4501000

“Physiological concentrations of the soy-derived isoflavone genistein were shown to downregulate the androgen receptor of PCa cells via the estrogen receptor β, resulting in a modified response to hormonal stimuli. They also inhibit several steroid-metabolizing enzymes such as 5-α-reductase or aromatase. It has been postulated that these activities may be protective for PCa by creating a more favorable hormonal milieu.”

ncbi.nlm.nih.gov/pmc/articl...

“Genistein reduces ER-β promoter methylation significantly in prostate cancer cells

This is accompanied by dose-dependent increases in ER-β protein and mRNA expression

It also induces nuclear translocation and activity of ER-β in prostate cancer cells

Genistein inhibits the proliferation of PCa cells with wild type androgen receptor

Blocking ER-β abolished the inhibitory effects of genistein on cell proliferation"

[Tall_Allen]

"After adjustment for confounders, an increased risk of advanced prostate cancer was found for the dietary intake of total isoflavones , genistein, daidzein and glycitein...This study revealed that dietary intake of isoflavones was associated with an elevated risk of advanced prostate cancer."

onlinelibrary.wiley.com/doi...

[Hidden in reply to Tall_Allen]

Perhaps increases the risk of occurrence if you are trying to prevent PCa and are on a standard diet with "normal" hormones/etc.

Since genistein is a SERM and preferentially binds to ERb I think it would block its action. Not good in general and even worse if you inhibit DHT.

I'm curious about other interactions with ERb in a high testosterone environment for existing PCa. What do you think?

[Tall_Allen in reply to Hidden]

Clinical studies trump lab studies. Randomized clinical trials trump observational clinical studies. It's important not to take mouse studies very seriously.

[dhccpa]

Haven't taken genestein yet but I do take a variety of supplements, pausing them and rotating off to other supplements periodically. I'm on Lupron so it's difficult to know what is working. But latest scans looked good even compared with earlier scans done after I had been on Lupron more than a year. We'll see.

[Hidden in reply to dhccpa]

I don't think I'll be taking genistein. Since it has an affinity to ERb I thought it might activate it similar to estrogens. But I think it just passively takes up the spot and therefore blocks any potential estrogen-ERb action. So, bad for PCa (ERb activity is good).

Same thing for other soy isoflavones. Perhaps I could find a substance that binds to ERa and blocks it? (ERa activity is bad)

[dhccpa in reply to Hidden]

Have you read Edward Friedman's book about prostate cancer? I haven't but others have suggested I do. I think he gets directly into ERa and ERb.

[Hidden in reply to dhccpa]

I've read it numerous times. Excellent book.

[dhccpa in reply to Hidden]

I'd be curious to hear from others on this forum about that book. I know it is an alternative treatment book.

[j-o-h-n]

genestein sounds like a beer..... Bartender I'll have a bottle of genestein....(cold if you don't mind).....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/25/2020 11:24 AM DST

[jmurgia in reply to j-o-h-n]

Ice Cold!

[j-o-h-n in reply to jmurgia]

As a witches broom.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 5:02 PM DST